ChEMBL ligand: CHEMBL15594 (Arachidonate, Arachidonic acid, Cis-5,8,11,14-Eicosatetraenoic Acid)
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
cPLA2-4C/Cytosolic phospholipase A2 gamma in Human [ChEMBL: CHEMBL4834] [GtoPdb: 1426] [UniProtKB: Q9UP65] There should be some charts here, you may need to enable JavaScript!
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090] There should be some charts here, you may need to enable JavaScript!
GroEL/GroES in Escherichia coli [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] There should be some charts here, you may need to enable JavaScript!
HSP60/HSP10 in Human [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] There should be some charts here, you may need to enable JavaScript!
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] There should be some charts here, you may need to enable JavaScript!
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050] There should be some charts here, you may need to enable JavaScript!
TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8] There should be some charts here, you may need to enable JavaScript!
K2P2.1 in Human [GtoPdb: 514] [UniProtKB: O95069] There should be some charts here, you may need to enable JavaScript!
K2P3.1 in Human [GtoPdb: 515] [UniProtKB: O14649] There should be some charts here, you may need to enable JavaScript!
Kv4.2 in Rat [GtoPdb: 553] [UniProtKB: Q63881] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL	Inhibition of FAAH	B	4	pIC50	>100000	nM	IC50	J. Med. Chem. (2008) 51: 7327-7343 [PMID:18983142]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Inhibition of aromatase in human placental microsomes by radiometric method	B	4.55	pIC50	28200	nM	IC50	J. Nat. Prod. (2006) 69: 700-703 [PMID:16643058]
cPLA2-4C/Cytosolic phospholipase A2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4834] [GtoPdb: 1426] [UniProtKB: Q9UP65]
ChEMBL	Concentration required to inhibit human Cytosolic phospholipase A2	B	4	pIC50	>100000	nM	IC50	Bioorg. Med. Chem. Lett. (2001) 11: 587-590 [PMID:11229777]
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090]
ChEMBL	Binding affinity against Adipocyte lipid binding protein	B	6.74	pKd	180	nM	Kd	J. Med. Chem. (2002) 45: 2469-2483 [PMID:12036355]
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6]
ChEMBL	Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis	B	4.74	pIC50	18000	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
ChEMBL	Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis	B	5.14	pIC50	7300	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604]
ChEMBL	Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by malachite green dye based spectrometric analysis	B	5.35	pIC50	4500	nM	IC50	Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084]
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL	Inhibition of PPAR-alpha (unknown origin) by SPA assay	B	5.92	pIC50	1200	nM	IC50	Med Chem Res (2009) 18: 8-19
ChEMBL	Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay	B	5.92	pIC50	1200	nM	IC50	Med Chem Res (2013) 22: 3126-3133
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
ChEMBL	Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay	B	5.51	pIC50	3100	nM	IC50	Med Chem Res (2013) 22: 3126-3133
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay	B	5.8	pIC50	1600	nM	IC50	Med Chem Res (2013) 22: 3126-3133
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2]
ChEMBL	Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry	B	5	pIC50	>10000	nM	IC50	J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
ChEMBL	Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry	B	5	pIC50	>10000	nM	IC50	J Med Chem (2018) 61: 8255-8281 [PMID:30176215]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002]
ChEMBL	Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes	F	5.07	pIC50	8500	nM	IC50	Journal of Applied Toxicology (2012) 32: 858-866 [PMID:22761000]
ChEMBL	Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes	F	5.24	pIC50	5800	nM	IC50	Journal of Applied Toxicology (2012) 32: 858-866 [PMID:22761000]
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050]
GtoPdb	-	-	6.35	pEC50	-	-	-	Mol Pharmacol (2001) 59: 1061-8 [PMID:11306688]
TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8]
GtoPdb	-	-	5	pEC50	-	-	-	Nature (2003) 424: 434-8 [PMID:12879072]
K2P2.1 in Human [GtoPdb: 514] [UniProtKB: O95069]
GtoPdb	-	-	5	pEC50	10000	nM	EC50	EMBO J (1998) 17: 4283-90 [PMID:9687497]
K2P3.1 in Human [GtoPdb: 515] [UniProtKB: O14649]
GtoPdb	-	-	1	pIC50	-	-	-	EMBO J (2001) 20: 47-54 [PMID:11226154]
Kv4.2 in Rat [GtoPdb: 553] [UniProtKB: Q63881]
GtoPdb	-	-	5.7	pIC50	-	-	-	Life Sci (1999) 65: PL143-9 [PMID:10503950]; J Neurosci (1996) 16: 2522-32 [PMID:8786428]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]