Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL15594 (Arachidonate, Arachidonic acid, Cis-5,8,11,14-Eicosatetraenoic Acid) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
ChEMBL | Inhibition of FAAH | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2008) 51: 7327-7343 [PMID:18983142] |
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
ChEMBL | Inhibition of aromatase in human placental microsomes by radiometric method | B | 4.55 | pIC50 | 28200 | nM | IC50 | J Nat Prod (2006) 69: 700-703 [PMID:16643058] |
cPLA2-4C/Cytosolic phospholipase A2 gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4834] [GtoPdb: 1426] [UniProtKB: Q9UP65] | ||||||||
ChEMBL | Concentration required to inhibit human Cytosolic phospholipase A2 | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 587-590 [PMID:11229777] |
fatty acid binding protein 4/Fatty acid binding protein adipocyte in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2083] [GtoPdb: 2534] [UniProtKB: P15090] | ||||||||
ChEMBL | Binding affinity against Adipocyte lipid binding protein | B | 6.74 | pKd | 180 | nM | Kd | J Med Chem (2002) 45: 2469-2483 [PMID:12036355] |
ChEMBL | Inhibition of FABP4 (unknown origin) | B | 5.29 | pIC50 | 5130 | nM | IC50 | Eur J Med Chem (2017) 138: 854-873 [PMID:28738306] |
ChEMBL | Inhibition of FABP4 (unknown origin) incubated for 10 mins by fluorescence based analysis | B | 5.56 | pIC50 | 2750 | nM | IC50 | Eur J Med Chem (2022) 240: 114604-114604 [PMID:35849941] |
GroEL/GroES in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106139] [UniProtKB: Q548M1, Q7BGE6] | ||||||||
ChEMBL | Inhibition of Escherichia coli GroEL expressed in Escherichia coli DH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured rhodanese refolding by measuring rhodanese enzyme activity after 45 mins by Fe(SCN)3 dye based spectrometric analysis | B | 4.74 | pIC50 | 18000 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084] |
ChEMBL | Inhibition of Escherichia coli GroEL expressed in Escherichia coliDH5alpha/Escherichia coli GroES expressed in Escherichia coli BL21 (DE3) assessed as reduction in GroEL/GroES-mediated denatured soluble pig heart MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 20 to 40 mins by malachite green dye based spectrometric analysis | B | 5.14 | pIC50 | 7300 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084] |
HSP60/HSP10 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4106131] [UniProtKB: P10809, P61604] | ||||||||
ChEMBL | Inhibition of human N-terminal octa-His-tagged HSP60 expressed in Escherichia coli Rosetta(DE3) pLysS/human HSP10 expressed in Escherichia coli Rosetta(DE3) assessed as reduction in HSP60/HSP10-mediated denatured MDH refolding by measuring MDH enzyme activity using sodium mesoxalate as substrate after 40 to 60 mins by malachite green dye based spectrometric analysis | B | 5.35 | pIC50 | 4500 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1106-1112 [PMID:30852084] |
Nuclear receptor related 1/Nuclear receptor subfamily 4 group A member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5002] [GtoPdb: 630] [UniProtKB: P43354] | ||||||||
ChEMBL | Binding affinity towards Nurr1 ligand binding domain (unknown origin) measured by tryptophan fluorescence spectroscopy | B | 4.3 | pKd | 50000 | nM | Kd | J Med Chem (2022) 65: 9548-9563 [PMID:35797147] |
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
ChEMBL | Inhibition of PPAR-alpha (unknown origin) by SPA assay | B | 5.92 | pIC50 | 1200 | nM | IC50 | Med Chem Res (2009) 18: 8-19 |
ChEMBL | Displacement of [3H]GW2331 from Homo sapiens (human) PPARalpha receptor by scintillation proximity assay | B | 5.92 | pIC50 | 1200 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] | ||||||||
ChEMBL | Displacement of [3H]GW2433 from Homo sapiens (human) PPARdelta receptor by scintillation proximity assay | B | 5.51 | pIC50 | 3100 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] | ||||||||
ChEMBL | Displacement of [3H]BRL49653 from Homo sapiens (human) PPARgamma receptor by scintillation proximity assay | B | 5.8 | pIC50 | 1600 | nM | IC50 | Med Chem Res (2013) 22: 3126-3133 |
Serine/threonine-protein phosphatase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3425389] [UniProtKB: P53041] | ||||||||
ChEMBL | Activation of recombinant human PP5 (16 to 499 residues) Escherichia coli BL21 (DE3) using pNPP incubated for 60 mins | B | 4.11 | pEC50 | 78000 | nM | EC50 | J Med Chem (2021) 64: 8916-8938 [PMID:34156850] |
TRPV2/Transient receptor potential cation channel subfamily V member 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2863] [GtoPdb: 508] [UniProtKB: Q9WUD2] | ||||||||
ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of LPC-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
ChEMBL | Antagonist activity at recombinant rat TRPV2 expressed in HEK293 cells assessed as inhibition of CBD-induced Ca2+ levels preincubated for 5 mins followed by agonist addition by Fuo-4-AM based spectrofluorimetry | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2018) 61: 8255-8281 [PMID:30176215] |
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes | F | 5.07 | pIC50 | 8500 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes | F | 5.24 | pIC50 | 5800 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
Kir2.3 in Human [GtoPdb: 432] [UniProtKB: P48050] | ||||||||
GtoPdb | - | - | 6.35 | pEC50 | - | - | - | Mol Pharmacol (2001) 59: 1061-8 [PMID:11306688] |
TRPV4 in Mouse [GtoPdb: 510] [UniProtKB: Q9EPK8] | ||||||||
GtoPdb | - | - | 5 | pEC50 | - | - | - | Nature (2003) 424: 434-8 [PMID:12879072] |
K2P2.1 in Human [GtoPdb: 514] [UniProtKB: O95069] | ||||||||
GtoPdb | - | - | 5 | pEC50 | 10000 | nM | EC50 | EMBO J (1998) 17: 4283-90 [PMID:9687497] |
K2P3.1 in Human [GtoPdb: 515] [UniProtKB: O14649] | ||||||||
GtoPdb | - | - | 1 | pIC50 | - | - | - | EMBO J (2001) 20: 47-54 [PMID:11226154] |
Kv4.2 in Rat [GtoPdb: 553] [UniProtKB: Q63881] | ||||||||
GtoPdb | - | - | 5.7 | pIC50 | - | - | - |
Life Sci (1999) 65: PL143-9 [PMID:10503950]; J Neurosci (1996) 16: 2522-32 [PMID:8786428] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]