garcinoic acid [Ligand Id: 10734] activity data from GtoPdb

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  • Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Pregnane X receptor in Human [GtoPdb: 606] [UniProtKB: O75469]
GtoPdb Binding affinity to hPXR ligand binding domain determined using an isothermic titration calorimetry (ITC) assay. - 6.48 pKd 330 nM Kd J Med Chem (2020) 63: 3701-3712 [PMID:32160459]
GtoPdb Agonist activity determined using a proprietary AlphaScreen method. - 5.89 pEC50 1300 nM EC50 J Med Chem (2020) 63: 3701-3712 [PMID:32160459]

Our curators have not yet identified this ligand in ChEMBL, but you may find additional data by searching on the ChEMBL site using the ligand's name or structure.