remdesivir [Ligand Id: 10715] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4065616 (Gs-5734, GS 5734, GS-5734, Remdesivir, Veklury)
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  • CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
NS5 in Zika virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523952] [UniProtKB: A0A143MHK7]
ChEMBL Inhibition of Zika virus RNA-dependent RNA polymerase activity B 5.87 pIC50 1360 nM IC50 Eur J Med Chem (2021) 224: 113698-113698 [PMID:34274831]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL Inhibition of SARS-CoV-2 RdRp transfected in human HEK293T cells cotransfected nsp12 along with nsp14 and nsp10 B 5.51 pIC50 3110 nM IC50 Eur J Med Chem (2021) 223: 113622-113622 [PMID:34147744]
ChEMBL Inhibition of SARS-CoV-2 RdRP using ATP substrate preincubated with compound for 30 mins followed by substrate addition and measured after 30 mins by Alphascreen microplate reader analysis B 5.79 pIC50 1640 nM IC50 RSC Med Chem (2023) 14: 899-920 [PMID:37252103]
ChEMBL Inhibition of SARS-CoV-2 RdRp transfected in human HEK293T cells cotransfected with Cov-Gluc by Gaussia luciferase reporter gene method B 5.81 pIC50 1560 nM IC50 Eur J Med Chem (2021) 223: 113622-113622 [PMID:34147744]
ChEMBL Inhibition of SARS-CoV-2 RdRp transfected in human HEK293T cells cotransfected nsp12 B 5.92 pIC50 1190 nM IC50 Eur J Med Chem (2021) 223: 113622-113622 [PMID:34147744]
ChEMBL Inhibition of SARS-CoV-2 RdRp transfected in HEK293T cells incubated for 24 hrs by CCK-8 assay B 5.98 pEC50 1050 nM EC50 Eur J Med Chem (2023) 252: 115292-115292 [PMID:36965227]
ChEMBL Inhibition of SARS-CoV-2 RdRp transfected in human A549 cells incubated for 24 hrs by CCK-8 assay B 6.14 pEC50 730 nM EC50 Eur J Med Chem (2023) 252: 115292-115292 [PMID:36965227]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]