betulinic acid [Ligand Id: 3945] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL269277
  • Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
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  • aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
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  • Botulinum neurotoxin type A in Clostridium botulinum [ChEMBL: CHEMBL5192] [UniProtKB: P0DPI0]
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  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
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  • Glycogen phosphorylase, muscle form in Rabbit [ChEMBL: CHEMBL4696] [UniProtKB: P00489]
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  • GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
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  • Liver X receptor-α/LXR-alpha in Human [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
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  • Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Mouse [ChEMBL: CHEMBL2459] [GtoPdb: 595] [UniProtKB: P37238]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction B 5.7 pIC50 2000 nM IC50 J. Nat. Prod. (2011) 74: 1201-1206 [PMID:21561086]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL Inhibition of reductase activity of N-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3) assessed as assessed as pyridine-3-aldehyde reduction B 4.96 pIC50 11000 nM IC50 J. Nat. Prod. (2011) 74: 1201-1206 [PMID:21561086]
Botulinum neurotoxin type A in Clostridium botulinum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5192] [UniProtKB: P0DPI0]
ChEMBL Inhibition of Clostridium BoNT/A protease light chain B 4.84 pKi 14300 nM Ki Bioorg. Med. Chem. Lett. (2011) 21: 2229-2231 [PMID:21421315]
ChEMBL Inhibition of Clostridium BoNT/A protease light chain B 4.7 pIC50 20000 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 2229-2231 [PMID:21421315]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of human DPP4 using H-Gly-Pro-AMC peptide substrate assessed as increase in fluorescence for 20 mins by fluorimetric assay B 4.25 pIC50 55820 nM IC50 MedChemComm (2011) 2: 471-477
DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [UniProtKB: P06746]
ChEMBL Inhibition of polymerase activity of DNA polymerase beta B 4.33 pIC50 46250 nM IC50 Bioorg. Med. Chem. (2008) 16: 4331-4340 [PMID:18343122]
ChEMBL Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay B 4.36 pIC50 43600 nM IC50 J. Nat. Prod. (2003) 66: 1463-1465 [PMID:14640519]
ChEMBL Inhibition of lyase activity of DNA polymerase beta B 4.47 pIC50 33700 nM IC50 Bioorg. Med. Chem. (2008) 16: 4331-4340 [PMID:18343122]
DNA polymerase beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4343] [UniProtKB: P06766]
ChEMBL Inhibition of rat DNA polymerase beta in presence of 0.1 mg/mL BSA B 4.85 pIC50 14000 nM IC50 J. Nat. Prod. (1999) 62: 1660-1663 [PMID:10654414]
ChEMBL Inhibition of rat DNA polymerase beta in absence of BSA B 5.19 pIC50 6500 nM IC50 J. Nat. Prod. (1999) 62: 1660-1663 [PMID:10654414]
Glycogen phosphorylase, muscle form in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4696] [UniProtKB: P00489]
ChEMBL Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate B 4.37 pIC50 43000 nM IC50 J. Med. Chem. (2008) 51: 3540-3554 [PMID:18517260]
ChEMBL Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method B 4.37 pIC50 43000 nM IC50 Eur. J. Med. Chem. (2011) 46: 2011-2021 [PMID:21439694]
ChEMBL Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method B 4.37 pIC50 42657.95 nM IC50 Eur. J. Med. Chem. (2011) 46: 2011-2021 [PMID:21439694]
GP41 in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559676] [UniProtKB: Q76270]
ChEMBL Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells after 6 to 8 hrs by luciferase assay B 4 pEC50 >100000 nM EC50 J. Med. Chem. (2014) 57: 7342-7354 [PMID:25156906]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
GtoPdb - - 5.98 pEC50 1040 nM EC50 J. Med. Chem. (2010) 53: 178-90 [PMID:19911773]
ChEMBL Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay F 5.98 pEC50 1040 nM EC50 J. Med. Chem. (2010) 53: 178-190 [PMID:19911773]
Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
ChEMBL Agonist activity at human recombinant LXRalpha expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRalpha ligand binding domain by HTRF assay B 4.3 pEC50 >50000 nM EC50 J. Nat. Prod. (2005) 68: 1247-1252 [PMID:16124770]
Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
ChEMBL Agonist activity at human recombinant LXRbeta expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRbeta ligand binding domain by HTRF assay B 4.3 pEC50 >50000 nM EC50 J. Nat. Prod. (2005) 68: 1247-1252 [PMID:16124770]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2459] [GtoPdb: 595] [UniProtKB: P37238]
ChEMBL Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay B 4 pEC50 >100000 nM EC50 J. Nat. Prod. (2014) 77: 1594-1600 [PMID:24955889]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 rings after 48 hrs by FACS analysis F 5.28 pIC50 5200 nM IC50 J. Nat. Prod. (2009) 72: 2130-2134 [PMID:19904919]
ChEMBL Antiplasmodial activity against Plasmodium falciparum Dd2 incubated under low oxygen conditions after 72 hrs by SYBR green assay F 5.46 pIC50 3440 nM IC50 Bioorg. Med. Chem. (2016) 24: 2544-2548 [PMID:27112454]
Zinc finger protein GLI1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5461] [UniProtKB: P08151]
ChEMBL Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells by luciferase based reporter gene assay B 4.49 pIC50 32000 nM IC50 Bioorg. Med. Chem. (2008) 16: 9420-9424 [PMID:18842418]
ChEMBL Inhibition of Gli1-mediated transcription expressed in human PANC1 cells B 4.49 pIC50 32000 nM IC50 J. Med. Chem. (2009) 52: 3829-3845 [PMID:19309080]

ChEMBL data shown on this page come from version 25:

A.P. Bento, A. Gaulton, A. Hersey, et al. (2014). The ChEMBL bioactivity database: an update. Nucl. Acids Res. Database Issue. 42 D1083-D1090. [PMID:24214965]