ChEMBL ligand: CHEMBL269277 (ALS-357, .beta.-betulinic acid, Betulic acid, Betulinic acid, Lupatic acid, Mairin, NSC-113090, NSC-677578)
Aldo-keto reductase family 1 member B10 in Human [ChEMBL: CHEMBL5983] [UniProtKB: O60218] There should be some charts here, you may need to enable JavaScript!
aldo-keto reductase family 1 member B/Aldose reductase in Human [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] There should be some charts here, you may need to enable JavaScript!
Botulinum neurotoxin type A in Clostridium botulinum [ChEMBL: CHEMBL5192] [UniProtKB: P0DPI0] There should be some charts here, you may need to enable JavaScript!
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] There should be some charts here, you may need to enable JavaScript!
DNA polymerase beta in Human [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746] DNA polymerase beta in Rat [ChEMBL: CHEMBL4343] [GtoPdb: 3231] [UniProtKB: P06766] There should be some charts here, you may need to enable JavaScript!
Glycogen phosphorylase, muscle form in Rabbit [ChEMBL: CHEMBL4696] [UniProtKB: P00489] There should be some charts here, you may need to enable JavaScript!
GP41 in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3559676] [UniProtKB: Q76270] There should be some charts here, you may need to enable JavaScript!
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-α/LXR-alpha in Human [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133] There should be some charts here, you may need to enable JavaScript!
Liver X receptor-β/LXR-beta in Human [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055] There should be some charts here, you may need to enable JavaScript!
Nonstructural protein 5 in Dengue virus [ChEMBL: CHEMBL4295629] [UniProtKB: V5TFZ2] There should be some charts here, you may need to enable JavaScript!
Nuclear factor NF-kappa-B p65 subunit in Human [ChEMBL: CHEMBL5533] [UniProtKB: Q04206] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Mouse [ChEMBL: CHEMBL2459] [GtoPdb: 595] [UniProtKB: P37238] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031] There should be some charts here, you may need to enable JavaScript!
Zinc finger protein GLI1 in Human [ChEMBL: CHEMBL5461] [UniProtKB: P08151] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218]
ChEMBL	Inhibition of reductase activity of N-terminal 6His-tagged human AKR1B10 expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction	B	5.7	pIC50	2000	nM	IC50	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121]
ChEMBL	Inhibition of reductase activity of N-terminal 6His-tagged human recombinant AKR1B1 expressed in Escherichia coli BL21(DE3) assessed as assessed as pyridine-3-aldehyde reduction	B	4.96	pIC50	11000	nM	IC50	J Nat Prod (2011) 74: 1201-1206 [PMID:21561086]
Botulinum neurotoxin type A in Clostridium botulinum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5192] [UniProtKB: P0DPI0]
ChEMBL	Inhibition of Clostridium BoNT/A protease light chain	B	4.84	pKi	14300	nM	Ki	Bioorg Med Chem Lett (2011) 21: 2229-2231 [PMID:21421315]
ChEMBL	Inhibition of Clostridium BoNT/A protease light chain	B	4.7	pIC50	20000	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2229-2231 [PMID:21421315]
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL	Inhibition of human DPP4 using H-Gly-Pro-AMC peptide substrate assessed as increase in fluorescence for 20 mins by fluorimetric assay	B	4.25	pIC50	55820	nM	IC50	Medchemcomm (2011) 2: 471-477
DNA polymerase beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2392] [GtoPdb: 3231] [UniProtKB: P06746]
ChEMBL	Inhibition of polymerase activity of DNA polymerase beta	B	4.33	pIC50	46250	nM	IC50	Bioorg Med Chem (2008) 16: 4331-4340 [PMID:18343122]
ChEMBL	Inhibition of DNA polymerase beta lyase activity by deoxyribose phosphate excision assay	B	4.36	pIC50	43600	nM	IC50	J Nat Prod (2003) 66: 1463-1465 [PMID:14640519]
ChEMBL	Inhibition of lyase activity of DNA polymerase beta	B	4.47	pIC50	33700	nM	IC50	Bioorg Med Chem (2008) 16: 4331-4340 [PMID:18343122]
DNA polymerase beta in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4343] [GtoPdb: 3231] [UniProtKB: P06766]
ChEMBL	Inhibition of rat DNA polymerase beta in presence of 0.1 mg/mL BSA	B	4.85	pIC50	14000	nM	IC50	J Nat Prod (1999) 62: 1660-1663 [PMID:10654414]
ChEMBL	Inhibition of rat DNA polymerase beta in absence of BSA	B	5.19	pIC50	6500	nM	IC50	J Nat Prod (1999) 62: 1660-1663 [PMID:10654414]
Glycogen phosphorylase, muscle form in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4696] [UniProtKB: P00489]
ChEMBL	Inhibition of rabbit muscle glycogen phosphorylase A assessed as phosphate release from glucose-1-phosphate	B	4.37	pIC50	43000	nM	IC50	J Med Chem (2008) 51: 3540-3554 [PMID:18517260]
ChEMBL	Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method	B	4.37	pIC50	43000	nM	IC50	Eur J Med Chem (2011) 46: 2011-2021 [PMID:21439694]
ChEMBL	Inhibition of rabbit muscle glycogen phosphorylase A assessed as release of phosphate from glucose-1-phosphate after 25 mins by microplate reader based method	B	4.37	pIC50	42657.95	nM	IC50	Eur J Med Chem (2011) 46: 2011-2021 [PMID:21439694]
GP41 in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3559676] [UniProtKB: Q76270]
ChEMBL	Inhibition of HIV1 gp41-induced cell-cell fusion between viral envelope expressing human HL2/3 cells to CD4/CCR5 receptor expressing TZM-bl cells after 6 to 8 hrs by luciferase assay	B	4	pEC50	>100000	nM	EC50	J Med Chem (2014) 57: 7342-7354 [PMID:25156906]
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
GtoPdb	-	-	5.98	pEC50	1040	nM	EC50	J Med Chem (2010) 53: 178-90 [PMID:19911773]
ChEMBL	Agonist activity at TGR5 expressed in CHO cells by CRE-driven luciferase reporter gene assay	F	5.98	pEC50	1040	nM	EC50	J Med Chem (2010) 53: 178-190 [PMID:19911773]
Liver X receptor-α/LXR-alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2808] [GtoPdb: 602] [UniProtKB: Q13133]
ChEMBL	Agonist activity at human recombinant LXRalpha expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRalpha ligand binding domain by HTRF assay	B	4.3	pEC50	>50000	nM	EC50	J Nat Prod (2005) 68: 1247-1252 [PMID:16124770]
Liver X receptor-β/LXR-beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4093] [GtoPdb: 601] [UniProtKB: P55055]
ChEMBL	Agonist activity at human recombinant LXRbeta expressed in Escherichia coli BL21 cells assessed as association of recombinant SRC1 to LXRbeta ligand binding domain by HTRF assay	B	4.3	pEC50	>50000	nM	EC50	J Nat Prod (2005) 68: 1247-1252 [PMID:16124770]
Nonstructural protein 5 in Dengue virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4295629] [UniProtKB: V5TFZ2]
ChEMBL	Inhibition of dengue virus NS5 RNA dependent RNA polymerase	B	5.77	pIC50	1700	nM	IC50	Eur J Med Chem (2019) 176: 431-455 [PMID:31128447]
Nuclear factor NF-kappa-B p65 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5533] [UniProtKB: Q04206]
ChEMBL	Inhibition of biotinylated consensus sequence binding to NF-kB p65 in human HeLa nuclear extracts after 3 hrs by ELISA	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem (2018) 26: 4452-4460 [PMID:30057155]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2459] [GtoPdb: 595] [UniProtKB: P37238]
ChEMBL	Agonist activity at mouse PPARgamma expressed in HEK293 cells co-expressing with Gal4 reporter vector after 24 hrs by dual-luciferase reporter assay	B	4	pEC50	>100000	nM	EC50	J Nat Prod (2014) 77: 1594-1600 [PMID:24955889]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes	F	4.89	pIC50	12780	nM	IC50	Bioorg Med Chem Lett (2018) 28: 265-272 [PMID:29326018]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 rings after 48 hrs by FACS analysis	F	5.28	pIC50	5200	nM	IC50	J Nat Prod (2009) 72: 2130-2134 [PMID:19904919]
ChEMBL	Antiplasmodial activity against Plasmodium falciparum Dd2 incubated under low oxygen conditions after 72 hrs by SYBR green assay	F	5.46	pIC50	3440	nM	IC50	Bioorg Med Chem (2016) 24: 2544-2548 [PMID:27112454]
ChEMBL	Antimalarial activity against ring stage Plasmodium falciparum 3D7 infected in type A-positive human erythrocytes after 72 hrs by SYBR green 1 dye-based fluorescence assay	F	5.85	pEC50	1419	nM	EC50	Bioorg Med Chem (2019) 27: 110-115 [PMID:30503412]
protein tyrosine phosphatase non-receptor type 1/Protein-tyrosine phosphatase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL335] [GtoPdb: 2976] [UniProtKB: P18031]
ChEMBL	Inhibition of PTP1B (unknown origin)	B	5.82	pIC50	1500	nM	IC50	Bioorg Med Chem (2021) 44: 116295-116295 [PMID:34246920]
Zinc finger protein GLI1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5461] [UniProtKB: P08151]
ChEMBL	Inhibition of GLI1-mediated transcriptional activity in human HaCaT cells by luciferase based reporter gene assay	B	4.49	pIC50	32000	nM	IC50	Bioorg Med Chem (2008) 16: 9420-9424 [PMID:18842418]
ChEMBL	Inhibition of Gli1-mediated transcription expressed in human PANC1 cells	B	4.49	pIC50	32000	nM	IC50	J Med Chem (2009) 52: 3829-3845 [PMID:19309080]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]