ramelteon [Ligand Id: 1356] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1218 (Ramelteon, Rozerem, TAK-375, TAK375) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039] | ||||||||
| ChEMBL | Binding affinity to human MT1 expressed in CHO cells | B | 10.85 | pKi | 0.01 | nM | Ki | J Med Chem (2021) 64: 3059-3074 [PMID:33682410] |
| ChEMBL | Binding affinity against human Melatonin receptor type 1A (MT1) | B | 10.86 | pKi | 0.01 | nM | Ki | J Med Chem (2002) 45: 4222-4239 [PMID:12213063] |
| GtoPdb | - | - | 10.9 | pKi | - | - | - | Neuropharmacology (2005) 48: 301-10 [PMID:15695169] |
| MT2 receptor/Melatonin receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286] | ||||||||
| ChEMBL | Binding affinity to human MT2 expressed in CHO cells | B | 9.95 | pKi | 0.11 | nM | Ki | J Med Chem (2021) 64: 3059-3074 [PMID:33682410] |
| GtoPdb | - | - | 10 | pKi | - | - | - |
Neuropharmacology (2005) 48: 301-10 [PMID:15695169]; Chronobiol Int (2011) 28: 31-8 [PMID:21182402] |
| ChEMBL | Binding affinity against human Melatonin receptor type 1B (MT2) | B | 10.35 | pKi | 0.04 | nM | Ki | J Med Chem (2002) 45: 4222-4239 [PMID:12213063] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
