ChEMBL ligand: CHEMBL411729
Glucose transporter 1/Solute carrier family 2, facilitated glucose transporter member 1 in Human [ChEMBL: CHEMBL2535] [GtoPdb: 875] [UniProtKB: P11166] There should be some charts here, you may need to enable JavaScript!
Glucose transporter 2/Solute carrier family 2, facilitated glucose transporter member 2 in Human [ChEMBL: CHEMBL5873] [GtoPdb: 876] [UniProtKB: P11168] There should be some charts here, you may need to enable JavaScript!
Glucose transporter 3/Solute carrier family 2, facilitated glucose transporter member 3 in Human [ChEMBL: CHEMBL5215] [GtoPdb: 877] [UniProtKB: P11169] There should be some charts here, you may need to enable JavaScript!
Glucose transporter 4/Solute carrier family 2, facilitated glucose transporter member 4 in Human [ChEMBL: CHEMBL5874] [GtoPdb: 878] [UniProtKB: P14672] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Glucose transporter 1/Solute carrier family 2, facilitated glucose transporter member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2535] [GtoPdb: 875] [UniProtKB: P11166]
ChEMBL	Inhibition of the Glucose Transporter (GLUT1, SLC2A1) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A1 WT-OE cells (PubChem AID: 1794830)	F	5.39	pIC50	4100	nM	IC50	Flow cytometry transport assay for SLC2A1 using HEK293 JumpIN TRex SLC2A1 WT-OE cells
ChEMBL	Inhibition of human GLUT1 expressed in human DLD-1 cells assessed as reduction in glucose uptake by measuring decrease in ATP production incubated for 15 mins in presence of oxidative phosphorylation inhibitor rotenone by CellTiter-Glo Luminescent Cell Viability Assay	B	7	pIC50	100	nM	IC50	ChemMedChem (2016) 11: 2261-2271 [PMID:27552707]
Glucose transporter 2/Solute carrier family 2, facilitated glucose transporter member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5873] [GtoPdb: 876] [UniProtKB: P11168]
ChEMBL	Inhibition of the Glucose Transporter (GLUT2, SLC2A2) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A2 WT-OE cells (PubChem AID: 1794829)	F	5	pIC50	>10000	nM	IC50	Flow cytometry transport assay for SLC2A2 using HEK293 JumpIN TRex SLC2A2 WT-OE cells
ChEMBL	Inhibition of human GLUT2 expressed in CHO cells assessed as reduction in fructose uptake by measuring decrease in ATP production incubated for 15 mins in presence of oxidative phosphorylation inhibitor rotenone by CellTiter-Glo Luminescent Cell Viability Assay	B	5.55	pIC50	2800	nM	IC50	ChemMedChem (2016) 11: 2261-2271 [PMID:27552707]
Glucose transporter 3/Solute carrier family 2, facilitated glucose transporter member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5215] [GtoPdb: 877] [UniProtKB: P11169]
ChEMBL	Inhibition of the Glucose Transporter (GLUT3, SLC2A3) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A3 WT-OE cells (PubChem AID: 1794827)	F	5.41	pIC50	3900	nM	IC50	Flow cytometry transport assay for SLC2A3 using HEK293 JumpIN TRex SLC2A3 WT-OE cells
ChEMBL	Inhibition of human GLUT3 expressed in human GLUT1-/- DLD-1 cells assessed as reduction in glucose uptake by measuring decrease in ATP production incubated for 15 mins in presence of oxidative phosphorylation inhibitor rotenone by CellTiter-Glo Luminescent Cell Viability Assay	B	6.92	pIC50	120	nM	IC50	ChemMedChem (2016) 11: 2261-2271 [PMID:27552707]
Glucose transporter 4/Solute carrier family 2, facilitated glucose transporter member 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5874] [GtoPdb: 878] [UniProtKB: P14672]
ChEMBL	Inhibition of the Glucose Transporter (GLUT4, SLC2A4) as assessed by a FRET based flow cytometry assay using a genetically-encoded biosensor for measuring free glucose (FLII12Pglu-700uDelta6) in HEK293 JumpIN TRex SLC2A4 WT-OE cells (PubChem AID: 1794828)	F	5.41	pIC50	3900	nM	IC50	Flow cytometry transport assay for SLC2A4 using HEK293 JumpIN TRex SLC2A4 WT-OE cells
ChEMBL	Inhibition of human GLUT4 expressed in CHO cells assessed as reduction in glucose uptake by measuring decrease in ATP production preincubated for 20 mins followed by glucose addition and measured after 15 mins in presence of oxidative phosphorylation inhibitor rotenone by CellTiter-Glo Luminescent Cell Viability Assay	B	6.55	pIC50	280	nM	IC50	ChemMedChem (2016) 11: 2261-2271 [PMID:27552707]

ChEMBL data shown on this page come from version 36:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]