GSK2256294 [Ligand Id: 9718] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL3818875
  • epoxide hydrolase 2/Epoxide hydratase in Human [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
epoxide hydrolase 2/Epoxide hydratase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2409] [GtoPdb: 2970] [UniProtKB: P34913]
ChEMBL Inhibition of recombinant human sHE assessed as product formation preincubated for 30 mins followed by addition of (3-phenyl-cyano-(6-methoxy-2-naphthalenyl)methyl ester-2-oxirane-acetic acid as substrate measured after 30 mins by fluorescence analysis B 6.96 pIC50 110 nM IC50 MedChemComm (2016) 7: 1209-1216
GtoPdb In a biochemical enzyme assay. - 6.96 pIC50 110 nM IC50 Medchemcomm (2016) 7: 1209-1216
ChEMBL Inhibition of recombinant human sEH using MNPC as substrate by fluorescence-based assay B 10.57 pIC50 0.03 nM IC50 J Med Chem (2018) 61: 3541-3550 [PMID:29614224]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]