zalcitabine [Ligand Id: 4828] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL853 (Ddc (ddc), Dideoxycytidine, Hivid, NSC-606170, RO 24-2027/000, RO-24-2027000, RO-242027000, Zalcitabine, Zalcitabine (dideoxycytidine,ddc)) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CXCR4/C-X-C chemokine receptor type 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2107] [GtoPdb: 71] [UniProtKB: P61073] | ||||||||
| ChEMBL | Effective concentration for 50% protection of HIV-induced cytopathogenicity in MT-4 cells on the MTT assay | F | 7.06 | pEC50 | 88 | nM | EC50 | Bioorg Med Chem Lett (2001) 11: 1897-1902 [PMID:11459656] |
| Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547] | ||||||||
| ChEMBL | Inhibitory constant against HIV-1 reverse transcriptase | B | 7.29 | pKi | 51 | nM | Ki | J Med Chem (2005) 48: 2695-2700 [PMID:15801860] |
| ChEMBL | Effective concentration required to achieve 50% inhibition of HIV-1 LAI replication in human T4 lymphoblastoid CEM-SS cells. | F | 7.51 | pEC50 | 31 | nM | EC50 | J Med Chem (2000) 43: 1927-1939 [PMID:10821705] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
