BIO1211 [Ligand Id: 6589] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL88478 (BIO-1211)
  • integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)/Integrin alpha-4/beta-1 in Human [ChEMBL: CHEMBL1907599] [GtoPdb: 24552443] [UniProtKB: P05556P13612]
  • This target only has 1 pki data point
1 CHEMBL88478_lig_chart_1 Integrin alpha-4/beta-1 Human
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  • integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)/integrin, beta 7 subunit/Integrin alpha-4/beta-7 in Human [ChEMBL: CHEMBL2095184] [GtoPdb: 24432461] [UniProtKB: P13612P26010]
  • This target only has 0 pki data point
2 CHEMBL88478_lig_chart_2 Integrin alpha-4/beta-7 Human
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  • integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 5 subunit (fibronectin receptor, alpha polypeptide)/Integrin alpha-5/beta-1 in Human [ChEMBL: CHEMBL2095226] [GtoPdb: 24552444] [UniProtKB: P05556P08648]
  • This target only has 0 pki data point
3 CHEMBL88478_lig_chart_3 Integrin alpha-5/beta-1 Human
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  • integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human [ChEMBL: CHEMBL2093869] [GtoPdb: 24572441] [UniProtKB: P05106P08514]
  • This target only has 0 pki data point
4 CHEMBL88478_lig_chart_4 Integrin alpha-IIb/beta-3 Human
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  • integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human [ChEMBL: CHEMBL2096661] [GtoPdb: 24562451] [UniProtKB: P05107P05362P20701]
  • This target only has 0 pki data point
5 CHEMBL88478_lig_chart_5 Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 Human
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  • integrin α4β1 in Human [GtoPdb: 2580]
  • This target only has 0 pki data point
6 CHEMBL88478_lig_chart_6 integrin α4β1 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)/Integrin alpha-4/beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907599] [GtoPdb: 24552443] [UniProtKB: P05556P13612]
ChEMBL Displacement of [125I]-FN from human alpha4beta1 integrin expressed in human Jurkat cells by scintillation proximity assay B 8.82 pKi 1.5 nM Ki Eur. J. Med. Chem. (2014) 73: 225-232 [PMID:24412498]
ChEMBL Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1 B 8.12 pIC50 7.6 nM IC50 Eur. J. Med. Chem. (2014) 73: 225-232 [PMID:24412498]
ChEMBL Inhibition of human alpha4beta1 integrin expressed in human Jurkat cells assessed as inhibition of cell adhesion to VCAM-1 B 8.12 pIC50 7.6 nM IC50 ACS Med. Chem. Lett. (2015) 6: 701-706 [PMID:26101577]
ChEMBL Displacement of [125I]-FN from human alpha4beta1 integrin expressed in human Jurkat cells by scintillation proximity assay B 8.32 pIC50 4.8 nM IC50 Eur. J. Med. Chem. (2014) 73: 225-232 [PMID:24412498]
ChEMBL Inhibition of integrin alpha4-beta1 adhesion to Jurkat cells B 8.4 pIC50 4 nM IC50 J. Med. Chem. (1999) 42: 920-934 [PMID:10072689]
ChEMBL Inhibition of integrin alpha4-beta1 binding to VCAM-Ig B 9 pIC50 1 nM IC50 J. Med. Chem. (1999) 42: 920-934 [PMID:10072689]
ChEMBL Inhibition of VLA-4 receptor expressed in CHO cells B 9.3 pIC50 <0.5 nM IC50 Bioorg. Med. Chem. Lett. (2005) 15: 41-45 [PMID:15582407]
ChEMBL Inhibition of Integrin alpha-4-beta-1-mediated adhesion in human jurkat cells B 9.52 pIC50 0.3 nM IC50 Nat. Chem. Biol. (2006) 2: 381-389 [PMID:16767086]
ChEMBL Inhibition of [125I]VCAM-Ig binding to Alpha-4 beta-1 (VLA-4) of Jurkat cells B 9.89 pIC50 0.13 nM IC50 Bioorg. Med. Chem. Lett. (2002) 12: 685-688 [PMID:11844701]
ChEMBL Antagonistic activity against VLA-4 integrin of human jurkat cells using [125I]VCAM-Ig as radioligand F 9.89 pIC50 0.13 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 2709-2713 [PMID:11591507]
integrin, alpha 4 subunit (antigen CD49D, alpha 4 subunit of VLA-4 receptor)/integrin, beta 7 subunit/Integrin alpha-4/beta-7 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095184] [GtoPdb: 24432461] [UniProtKB: P13612P26010]
ChEMBL Inhibition of integrin alpha4-beta7 adhesion to JY cells B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (1999) 42: 920-934 [PMID:10072689]
ChEMBL Inhibition of [125I]MAdCAM-Ig binding to alpha4-beta7 integrin of human RPMI-8866 cells B 6.06 pIC50 862 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 2709-2713 [PMID:11591507]
ChEMBL Inhibition of [125I]VCAM-Ig binding to alpha4-beta7 integrin of human RPMI-8866 cells B 6.36 pIC50 433 nM IC50 Bioorg. Med. Chem. Lett. (2001) 11: 2709-2713 [PMID:11591507]
integrin, beta 1 subunit (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)/integrin, alpha 5 subunit (fibronectin receptor, alpha polypeptide)/Integrin alpha-5/beta-1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2095226] [GtoPdb: 24552444] [UniProtKB: P05556P08648]
ChEMBL Inhibition of integrin alpha5-beta1 adhesion to K562 cells B 4 pIC50 >100000 nM IC50 J. Med. Chem. (1999) 42: 920-934 [PMID:10072689]
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 24572441] [UniProtKB: P05106P08514]
ChEMBL Inhibition of integrin alphaIIb-beta3 adhesion to human citreated platelets B 4 pIC50 >100000 nM IC50 J. Med. Chem. (1999) 42: 920-934 [PMID:10072689]
integrin, beta 2 subunit (complement component 3 receptor 3 and 4 subunit)/integrin, alpha L subunit (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide)/Intercellular adhesion molecule (ICAM-1), Integrin alpha-L/beta-2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2096661] [GtoPdb: 24562451] [UniProtKB: P05107P05362P20701]
ChEMBL Inhibition of ICAM-1 transfected CHO cell adhesion to integrin alphaL-beta2 of human JY cells B 4 pIC50 >100000 nM IC50 J. Med. Chem. (1999) 42: 920-934 [PMID:10072689]
integrin α4β1 in Human [GtoPdb: 2580]
GtoPdb - - 9 pIC50 - - - J. Med. Chem. (1999) 42: 920-34 [PMID:10072689]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]