6-Cl-MLT [Ligand Id: 1346] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL34730 (6-Chloromelatonin)
  • MT1 receptor/Melatonin receptor 1A in Human [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039]
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  • MT2 receptor/Melatonin receptor 1B in Human [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
MT1 receptor/Melatonin receptor 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1945] [GtoPdb: 287] [UniProtKB: P48039]
ChEMBL Displacement of [125I]2-iodomelatonin from human recombinant MT1 receptor expressed in African green monkey COS7 cells B 7.94 pKi 11.4 nM Ki J. Med. Chem. (2014) 57: 3161-3185 [PMID:24228714]
GtoPdb - - 9.2 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (2003) 367: 553-61 [PMID:12764576];
Naunyn Schmiedebergs Arch. Pharmacol. (1997) 355: 365-75 [PMID:9089668];
J. Pharmacol. Exp. Ther. (1998) 285: 1239-45 [PMID:9618428];
J. Pharmacol. Exp. Ther. (1985) 234: 395-401 [PMID:2991499]
MT2 receptor/Melatonin receptor 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1946] [GtoPdb: 288] [UniProtKB: P49286]
ChEMBL Displacement of [125I]2-iodomelatonin from human recombinant MT2 receptor expressed in African green monkey COS7 cells B 9.7 pKi 0.2 nM Ki J. Med. Chem. (2014) 57: 3161-3185 [PMID:24228714]
GtoPdb - - 9.8 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (2003) 367: 553-61 [PMID:12764576];
Naunyn Schmiedebergs Arch. Pharmacol. (1997) 355: 365-75 [PMID:9089668];
J. Pharmacol. Exp. Ther. (1998) 285: 1239-45 [PMID:9618428];
J. Pharmacol. Exp. Ther. (1985) 234: 395-401 [PMID:2991499]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]