ONO-AE1-437 [Ligand Id: 8541] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL292964
  • EP1 receptor/Prostanoid EP1 receptor in Mouse [ChEMBL: CHEMBL2181] [GtoPdb: 340] [UniProtKB: P35375]
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  • EP2 receptor/Prostanoid EP2 receptor in Mouse [ChEMBL: CHEMBL2488] [GtoPdb: 341] [UniProtKB: Q62053]
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  • EP3 receptor/Prostanoid EP3 receptor in Mouse [ChEMBL: CHEMBL4336] [GtoPdb: 342] [UniProtKB: P30557]
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  • EP4 receptor/Prostanoid EP4 receptor in Mouse [ChEMBL: CHEMBL2489] [GtoPdb: 343] [UniProtKB: P32240]
  • EP4 receptor/Prostanoid EP4 receptor in Rat [ChEMBL: CHEMBL4086] [GtoPdb: 343] [UniProtKB: P43114]
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  • IP receptor/Prostanoid IP receptor in Human [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
EP1 receptor/Prostanoid EP1 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2181] [GtoPdb: 340] [UniProtKB: P35375]
ChEMBL Affinity for mouse Prostanoid EP1 receptor expressed in CHO cells B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 2033-2035 [PMID:11454474]
ChEMBL Displacement of [3H]-PGE2 from mouse EP1 receptor expressed in CHO cells after 20 mins by liquid scintillation counter B 5 pKi >10000 nM Ki Bioorg. Med. Chem. (2012) 20: 702-713 [PMID:22204740]
EP2 receptor/Prostanoid EP2 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2488] [GtoPdb: 341] [UniProtKB: Q62053]
ChEMBL Affinity for mouse Prostanoid EP2 receptor expressed in CHO cells B 6.21 pKi 620 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 2033-2035 [PMID:11454474]
ChEMBL Binding affinity to mouse EP2 receptor by competitive binding assay B 6.21 pKi 620 nM Ki J. Med. Chem. (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL Displacement of [3H]-PGE2 from mouse EP2 receptor expressed in CHO cells after 60 mins by liquid scintillation counter B 6.21 pKi 620 nM Ki Bioorg. Med. Chem. (2012) 20: 702-713 [PMID:22204740]
EP3 receptor/Prostanoid EP3 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4336] [GtoPdb: 342] [UniProtKB: P30557]
ChEMBL Affinity for mouse Prostanoid EP3 receptor expressed in CHO cells B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 2033-2035 [PMID:11454474]
ChEMBL Displacement of [3H]-PGE2 from mouse EP3 receptor expressed in CHO cells after 60 mins by liquid scintillation counter B 7.25 pKi 56 nM Ki Bioorg. Med. Chem. (2012) 20: 702-713 [PMID:22204740]
EP4 receptor/Prostanoid EP4 receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2489] [GtoPdb: 343] [UniProtKB: P32240]
GtoPdb - - 9.15 pKi 0.71 nM Ki Osteoarthr. Cartil. (2003) 11: 644-52 [PMID:12954235]
ChEMBL Affinity for mouse Prostanoid EP4 receptor expressed in CHO cells B 9.15 pKi 0.7 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 2033-2035 [PMID:11454474]
ChEMBL Binding affinity to mouse EP4 receptor by competitive binding assay B 9.15 pKi 0.7 nM Ki J. Med. Chem. (2010) 53: 4332-4353 [PMID:20218623]
ChEMBL Displacement of [3H]-PGE2 from mouse EP4 receptor expressed in CHO cells after 60 mins by liquid scintillation counter B 9.15 pKi 0.7 nM Ki Bioorg. Med. Chem. (2012) 20: 702-713 [PMID:22204740]
ChEMBL Effective concentration for increased intracellular c-AMP production by mouse Prostanoid EP4 receptor F 8.8 pEC50 1.6 nM EC50 Bioorg. Med. Chem. Lett. (2001) 11: 2033-2035 [PMID:11454474]
EP4 receptor/Prostanoid EP4 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4086] [GtoPdb: 343] [UniProtKB: P43114]
ChEMBL Agonist activity at rat EP4 receptor expressed in CHO cells assessed as cAMP production after 10 mins by radioimmunoassay F 8.85 pEC50 1.4 nM EC50 Bioorg. Med. Chem. (2012) 20: 702-713 [PMID:22204740]
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119]
ChEMBL Affinity for human Prostanoid IP receptor expressed in CHO cells B 5 pKi >10000 nM Ki Bioorg. Med. Chem. Lett. (2001) 11: 2033-2035 [PMID:11454474]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]