[3H]UBP310 [Ligand Id: 4092] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL373428 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluA2/Glutamate receptor ionotropic, AMPA 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4016] [GtoPdb: 445] [UniProtKB: P42262] | ||||||||
| ChEMBL | Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay | F | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2007) 50: 1558-1570 [PMID:17348638] |
| GluK1 in Human [GtoPdb: 450] [UniProtKB: P39086] | ||||||||
| GtoPdb | - | - | 7.7 | pKd | 21 | nM | Kd | Mol Pharmacol (2010) 78: 1036-45 [PMID:20837679] |
| GluK1/Glutamate receptor ionotropic kainate 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2919] [GtoPdb: 450] [UniProtKB: P22756] | ||||||||
| ChEMBL | Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibres | F | 7.74 | pKd | 18 | nM | Kd | J Med Chem (2007) 50: 1558-1570 [PMID:17348638] |
| GluK2/Glutamate receptor ionotropic kainate 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3683] [GtoPdb: 451] [UniProtKB: Q13002] | ||||||||
| ChEMBL | Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assay | F | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2007) 50: 1558-1570 [PMID:17348638] |
| GluK3 in Human [GtoPdb: 452] [UniProtKB: Q13003] | ||||||||
| GtoPdb | - | - | 6.3 | pKd | 560 | nM | Kd | Mol Pharmacol (2010) 78: 1036-45 [PMID:20837679] |
| GluK3/Glutamate receptor ionotropic kainate 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3744] [GtoPdb: 452] [UniProtKB: P42264] | ||||||||
| ChEMBL | Displacement of [3H]SYM2081 from rat GluK3 expressed in Sf9 cells | B | 7.64 | pKi | 23 | nM | Ki | J Med Chem (2011) 54: 4793-4805 [PMID:21619066] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
