PA452 [Ligand Id: 8905] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL115097
  • Retinoid X receptor-α/Retinoid X receptor alpha in Human [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Retinoid X receptor-α/Retinoid X receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2061] [GtoPdb: 610] [UniProtKB: P19793]
ChEMBL Antagonist activity at RXRalpha expressed in COS1 cells assessed as inhibition of NEt-TMN-induced luciferase activity after 18 hrs by reporter gene assay relative to LGD1069 F 7.11 pKd 77.62 nM Kd ACS Med. Chem. Lett. (2011) 2: 896-900 [PMID:24900278]
GtoPdb - - 7.11 pA2 - - - ACS Med Chem Lett (2011) 2: 896-900 [PMID:24900278]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]