Synonyms: compound 16 [PMID: 34423975] | ZN-c3 | ZNc3
Compound class:
Synthetic organic
Comment: ZN-c3 is a potent inhibitor of WEE1 G2 checkpoint kinase (WEE1) that was developed for anti-cancer potential [1]. Inhibition of Wee1 in cancer cells that rely on G2/M checkpoint regulation for survival, disrupts G2/M cell cycle arrest which leads to premature entry into mitosis, replication stress and ultimately cell death. The chemical structure of ZN-c3 matches that for the INN 'azenosertib' which was published in the WHO's proposed INN list 127 on 21 July 2022.
![]() Ligand Activity Visualisation ChartsThese are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts. ✖ |
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
1-[(7R)-7-ethyl-7-hydroxy-5,6-dihydrocyclopenta[b]pyridin-2-yl]-6-[4-(4-methylpiperazin-1-yl)anilino]-2-prop-2-enylpyrazolo[3,4-d]pyrimidin-3-one |
Synonyms ![]() |
compound 16 [PMID: 34423975] | ZN-c3 | ZNc3 |
Database Links ![]() |
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CAS Registry No. | 2376146-48-2 (source: WHO INN record) |
GtoPdb PubChem SID | 458923766 |
PubChem CID | 139467635 |
RCSB PDB Ligand | 05J |
Search Google for chemical match using the InChIKey | OXTSYWDBUVRXFF-GDLZYMKVSA-N |
Search Google for chemicals with the same backbone | OXTSYWDBUVRXFF |
UniChem Compound Search for chemical match using the InChIKey | OXTSYWDBUVRXFF-GDLZYMKVSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | OXTSYWDBUVRXFF-GDLZYMKVSA-N |