Synonyms: H 151 | H151
Compound class:
Synthetic organic
Comment: H-151 is a small molecule covalent STING antagonist [2]. Mechanistically it binds to Cys91 of the protein and prevents its palmitoylation. The non-modified STING protein is then unable to assemble the STING complexes that are essential to activate downstream processes (e.g. Type I interferon response). H-151 has been reported to reduce SARS-CoV-2-induced lung inflammation and to improve disease outcome in ACE2-humanised mice [1].
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Classification ![]() |
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Compound class | Synthetic organic |
IUPAC Name ![]() |
3-(4-ethylphenyl)-1-(1H-indol-3-yl)urea |
Synonyms ![]() |
H 151 | H151 |
Database Links ![]() |
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CAS Registry No. | 941987-60-6 (source: PubChem) |
GtoPdb PubChem SID | 381118832 |
PubChem CID | 7616033 |
Search Google for chemical match using the InChIKey | UJZDIKVQFMCLBE-UHFFFAOYSA-N |
Search Google for chemicals with the same backbone | UJZDIKVQFMCLBE |
UniChem Compound Search for chemical match using the InChIKey | UJZDIKVQFMCLBE-UHFFFAOYSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | UJZDIKVQFMCLBE-UHFFFAOYSA-N |