JNJ-5207787 [Ligand Id: 3504] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL21283 (JNJ-5207787) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Y2 receptor/Neuropeptide Y receptor type 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4018] [GtoPdb: 306] [UniProtKB: P49146] | ||||||||
| ChEMBL | Binding affinity towards human NPY Y2 receptor was determined using [35S]GTP-gamma-S, radioligand | F | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1239-1242 [PMID:14980673] |
| ChEMBL | Binding affinity to neuropeptide Y2 receptor | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4022-4025 [PMID:19581086] |
| ChEMBL | Displacement of [125I]PYY from human NPY Y2 receptor expressed endogenously in KAN-Ts cells by scintillation counting | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 5552-5556 [PMID:21802951] |
| ChEMBL | Displacement of [125I]-NPY from NPYY2 receptor (unknown origin) | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 430-441 [PMID:24365162] |
| GtoPdb | - | - | 7.1 | pIC50 | - | - | - | J Pharmacol Exp Ther (2004) 308: 1130-7 [PMID:14617685] |
| ChEMBL | Antagonist activity at human neuropeptide Y2 receptor by [35]GTPgammaS assay | F | 7.2 | pIC50 | 63.1 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 4022-4025 [PMID:19581086] |
| ChEMBL | Antagonist activity at NPYY2 receptor (unknown origin) assessed as inhibition of PYY-induced [33S]-GTPgammaS binding | F | 7.2 | pIC50 | 63.1 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 430-441 [PMID:24365162] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
