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ChEMBL ligand: CHEMBL3771118 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Na+/dicarboxylate cotransporter 1/Solute carrier family 13 member 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3712851] [GtoPdb: 978] [UniProtKB: Q13183] | ||||||||
ChEMBL | Inhibition of NaDC1 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis | B | 4.88 | pIC50 | 13200 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
ChEMBL | Inhibition of NaDC1 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
Na+/dicarboxylate cotransporter 3/Solute carrier family 13 member 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3712947] [GtoPdb: 979] [UniProtKB: Q8WWT9] | ||||||||
ChEMBL | Inhibition of NaDC3 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis | B | 4.85 | pIC50 | 14100 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
ChEMBL | Inhibition of NaDC3 (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
Na+/citrate cotransporter/Solute carrier family 13 member 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769293] [GtoPdb: 981] [UniProtKB: Q86YT5] | ||||||||
ChEMBL | Inhibition of NaCT in human hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method | B | 6.1 | pIC50 | 794.33 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
ChEMBL | Inhibition of NaCT in human hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method | B | 6.13 | pIC50 | 740 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
GtoPdb | - | - | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2016) 59: 1165-75 [PMID:26734723] |
ChEMBL | Inhibition of NaCT (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis | B | 6.29 | pIC50 | 510 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
ChEMBL | Inhibition of NaCT (unknown origin) expressed in HEK293 cells assessed as inhibition of [14C]citrate uptake by microbeta plate reader analysis | B | 6.3 | pIC50 | 501.19 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
Na+/citrate cotransporter/Solute carrier family 13 member 5 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769294] [GtoPdb: 981] [UniProtKB: Q67BT3] | ||||||||
ChEMBL | Inhibition of NaCT in mouse hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method | B | 6.67 | pIC50 | 213.8 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
ChEMBL | Inhibition of NaCT in mouse hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
Na+/citrate cotransporter/Solute carrier family 13 member 5 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769295] [GtoPdb: 981] [UniProtKB: Q8CJ44] | ||||||||
ChEMBL | Inhibition of NaCT in rat hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method | B | 6.9 | pIC50 | 125.89 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
ChEMBL | Inhibition of NaCT in rat hepatocytes assessed as [14C]-citrate uptake after 30 mins by scintillation counting method | B | 6.92 | pIC50 | 120 | nM | IC50 | J Med Chem (2016) 59: 1165-1175 [PMID:26734723] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]