HEMADO [Ligand Id: 5599] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL260563
  • A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
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  • A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
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  • A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
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  • A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
GtoPdb - - 6.48 pKi 330 nM Ki J Med Chem (2002) 45: 3271-9 [PMID:12109910];
Eur J Pharmacol (2007) 556: 14-8 [PMID:17126322]
ChEMBL Binding affinity against Human recombinant Adenosine A1 receptor stably transfected in CHO cells using [3H]CCPA as radioligand B 6.49 pKi 327 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL Binding affinity against Human recombinant Adenosine A2A receptor stably transfected in CHO cells using [3H]NECA as radioligand B 5.91 pKi 1230 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
GtoPdb - - 5.92 pKi 1200 nM Ki J Med Chem (2002) 45: 3271-9 [PMID:12109910];
Eur J Pharmacol (2007) 556: 14-8 [PMID:17126322]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb - - 4.52 pKi >30000 nM Ki J Med Chem (2002) 45: 3271-9 [PMID:12109910];
Eur J Pharmacol (2007) 556: 14-8 [PMID:17126322]
ChEMBL Receptor-stimulated activity in CHO cells stably transfected with Human recombinant Adenosine A2B receptor using [3H]NECA as radioligand B 4 pEC50 100000 nM EC50 J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
ChEMBL Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase F 5 pEC50 -5 - logEC50 J Med Chem (2008) 51: 2088-2099 [PMID:18321038]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL Binding affinity against Human recombinant Adenosine A3 receptor stably transfected in CHO cells using [3H]NECA as radioligand B 8.96 pKi 1.1 nM Ki J Med Chem (2002) 45: 3271-3279 [PMID:12109910]
GtoPdb - - 8.96 pKi 1.1 nM Ki J Med Chem (2002) 45: 3271-9 [PMID:12109910];
Eur J Pharmacol (2007) 556: 14-8 [PMID:17126322]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]