TCDD [Ligand Id: 9642] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL30327 (2,3,7,8-Tetrachloro-Dibenzo[1,4]Dioxine)
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  • fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Aryl hydrocarbon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3201] [GtoPdb: 2951] [UniProtKB: P35869]
ChEMBL Affinity on cytosolic Aromatic hydrocarbon receptor (Ah) B 8 pEC50 10 nM EC50 J. Med. Chem. (1997) 40: 4360-4371 [PMID:9435905]
Aryl hydrocarbon receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6099] [GtoPdb: 2951] [UniProtKB: P30561]
ChEMBL Agonist activity at Ah receptor in genetically engineered mouse cells expressing firefly luciferase gene by CALUX transactivational assay F 10.52 pEC50 0.03 nM EC50 Bioorg. Med. Chem. Lett. (2011) 21: 6258-6263 [PMID:21958547]
fms related receptor tyrosine kinase 1/Vascular endothelial growth factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1868] [GtoPdb: 1812] [UniProtKB: P17948]
ChEMBL DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) B 9.16 pKi 0.7 nM Ki DrugMatrix in vitro pharmacology data
ChEMBL DRUGMATRIX: Vascular Endothelial Growth Factor (VEGF) radioligand binding (ligand: [125I] VEGF) B 8.57 pIC50 2.69 nM IC50 DrugMatrix in vitro pharmacology data

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]