ChEMBL ligand: CHEMBL2179656
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb	Binding affinity	-	8.29	pKi	5.1	nM	Ki	J Pain (2020) 21: 146-160 [PMID:31201990]
ChEMBL	Displacement of [3H]DADLE from human delta opioid receptor expressed in CHO cells by scintillation counting analysis	B	8.98	pKi	1.04	nM	Ki	J Med Chem (2012) 55: 8350-8363 [PMID:23016952]
GtoPdb	Potency in a 35S-GTPγS assay	-	8.89	pEC50	1.3	nM	EC50	J Pain (2020) 21: 146-160 [PMID:31201990]
ChEMBL	Agonist activity at delta opioid receptor expressed in rat/mouse NG108-15 cells assessed as [35S]GTPgammaS binding by scintillation counting analysis	F	9.57	pEC50	0.27	nM	EC50	J Med Chem (2012) 55: 8350-8363 [PMID:23016952]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]U69,593 from human kappa opioid receptor expressed in CHO cells by scintillation counting analysis	B	8.82	pKi	1.53	nM	Ki	J Med Chem (2012) 55: 8350-8363 [PMID:23016952]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb	Binding affinity	-	7.71	pKi	19.7	nM	Ki	J Pain (2020) 21: 146-160 [PMID:31201990]
ChEMBL	Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHO cells by scintillation counting analysis	B	9.27	pKi	0.54	nM	Ki	J Med Chem (2012) 55: 8350-8363 [PMID:23016952]
ChEMBL	Agonist activity at human mu opioid receptor expressed in CHO cells assessed as [35S]GTPgammaS binding by scintillation counting analysis	F	8.67	pEC50	2.15	nM	EC50	J Med Chem (2012) 55: 8350-8363 [PMID:23016952]
GtoPdb	Potency in a 35S-GTPγS assay	-	9.7	pEC50	0.2	nM	EC50	J Pain (2020) 21: 146-160 [PMID:31201990]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]