compound 45 [PMID: 8709105] [Ligand Id: 8809] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL328689
  • adenylyl cyclase 1/Brain adenylate cyclase 1 in Human [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828]
  • adenylyl cyclase 1 in Bovine [GtoPdb: 1278]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
adenylyl cyclase 1/Brain adenylate cyclase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828]
ChEMBL Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 B 6.82 pIC50 <150 nM IC50 J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105]
ChEMBL Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 B 7.68 pIC50 21 nM IC50 J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105]
ChEMBL Ability to activate the conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 F 5.7 pEC50 <2000 nM EC50 J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105]
ChEMBL Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 F 6.22 pEC50 600 nM EC50 J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105]
adenylyl cyclase 1 in Bovine [GtoPdb: 1278]
GtoPdb Measuring competitive inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1. - 7.68 pIC50 21 nM IC50 J Med Chem (1996) 39: 2745-52 [PMID:8709105]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]