compound 45 [PMID: 8709105] [Ligand Id: 8809] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL328689 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| adenylyl cyclase 1/Brain adenylate cyclase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828] | ||||||||
| ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 | B | 6.82 | pIC50 | <150 | nM | IC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Ability to activate the conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 | F | 5.7 | pEC50 | <2000 | nM | EC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 | F | 6.22 | pEC50 | 600 | nM | EC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| adenylyl cyclase 1 in Bovine [GtoPdb: 1278] | ||||||||
| GtoPdb | Measuring competitive inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1. | - | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (1996) 39: 2745-52 [PMID:8709105] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
