compound 45 [PMID: 8709105] [Ligand Id: 8809] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL328689 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| adenylyl cyclase 1/Brain adenylate cyclase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828] | ||||||||
| ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 | B | 6.82 | pIC50 | <150 | nM | IC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 | B | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Ability to activate the conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 | F | 5.7 | pEC50 | <2000 | nM | EC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| ChEMBL | Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 | F | 6.22 | pEC50 | 600 | nM | EC50 | J Med Chem (1996) 39: 2745-2752 [PMID:8709105] |
| adenylyl cyclase 1 in Bovine [GtoPdb: 1278] | ||||||||
| GtoPdb | Measuring competitive inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1. | - | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (1996) 39: 2745-52 [PMID:8709105] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
