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ChEMBL ligand: CHEMBL328689 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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adenylyl cyclase 1/Brain adenylate cyclase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2899] [GtoPdb: 1278] [UniProtKB: Q08828] | ||||||||
ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 | B | 6.82 | pIC50 | <150 | nM | IC50 | J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105] |
ChEMBL | Inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1 | B | 7.68 | pIC50 | 21 | nM | IC50 | J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105] |
ChEMBL | Ability to activate the conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 | F | 5.7 | pEC50 | <2000 | nM | EC50 | J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105] |
ChEMBL | Conversion of [32P] ATP to [32P]-cyclic AMP mediated by adenylate cyclase 1 | F | 6.22 | pEC50 | 600 | nM | EC50 | J. Med. Chem. (1996) 39: 2745-2752 [PMID:8709105] |
adenylyl cyclase 1 in Bovine [GtoPdb: 1278] | ||||||||
GtoPdb | Measuring competitive inhibition of [125 I]6-IHPP-forskolin binding to adenylate cyclase 1. | - | 7.68 | pIC50 | 21 | nM | IC50 | J Med Chem (1996) 39: 2745-52 [PMID:8709105] |
ChEMBL data shown on this page come from version 28:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]