niclosamide

Ligand id: 8494

Name: niclosamide

Structure and Physico-chemical Properties

2D Structure
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Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 92.47
Molecular weight 325.99
XLogP 4.15
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
Approved drug? Yes
WHO Essential Medicine WHO Model List of Essential Medicines (21st List, 2019). Access PDF version.
IUPAC Name
5-Chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Synonyms
VU0243604
Comments
STAT3 inhibitor; inhibits mTORC1 signaling; positive allosteric modulator (PAM) of the neuropeptide Y4 receptor [2].

Evidence from repurposing studies suggests some activity against methicillin-resistant Staphylococcus aureus (MRSA), and Zika virus (in vitro) [3].
Database Links
GtoPdb PubChem SID 252166702
PubChem CID 4477
Search Google for chemical match using the InChIKey RJMUSRYZPJIFPJ-UHFFFAOYSA-N
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Search UniChem for chemical match using the InChIKey RJMUSRYZPJIFPJ-UHFFFAOYSA-N
Search UniChem for chemicals with the same backbone RJMUSRYZPJIFPJ

Product suppliers

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Tocris
Niclosamide
Cat. No. 4079