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niclosamide is an approved drug
Compound class: Synthetic organic
Comment: Niclosamide is an oral anthelmintic drug but may have the potential to be used in broader clinical applications. Evidence from repurposing studies suggests some activity against methicillin-resistant Staphylococcus aureus (MRSA), and Zika virus (in vitro) .
It is a STAT3 inhibitor, inhibits mTORC1 signaling; positive allosteric modulator (PAM) of the neuropeptide Y4 receptor .
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|WHO Essential Medicine||WHO Essential Medicines List (EML) (23rd List, 2023). Access PDF version.
Click to view more information about the WHO Model Lists of Essential Medicines.
|GtoPdb PubChem SID||252166702|
|RCSB PDB Ligand||VUT|
|Search Google for chemical match using the InChIKey||RJMUSRYZPJIFPJ-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||RJMUSRYZPJIFPJ|
|UniChem Compound Search for chemical match using the InChIKey||RJMUSRYZPJIFPJ-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||RJMUSRYZPJIFPJ-UHFFFAOYSA-N|
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Niclosamide (links to external site)
Cat. No. 4079