tauroursodeoxycholic acid [Ligand Id: 4746] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL272427 (Tauroursodeoxycholic acid, Tauroursodesoxycholic acid, Taurursodiol, Taurursodiol component of relyvrio, Ur-906, Ursodeoxy cholic acid, Ursodeoxycholyltaurine, Ursodoxicoltaurine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| autotaxin/Autotaxin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3691] [GtoPdb: 2901] [UniProtKB: Q13822] | ||||||||
| ChEMBL | Inhibition of ATX (unknown origin) | B | 4.98 | pIC50 | 10400 | nM | IC50 | Eur J Med Chem (2024) 264: 116029-116029 [PMID:38091892] |
| ChEMBL | Inhibition of human ATX expressed in HEK293 Flp-In cells assessed as decrease in choline release from LPC measured every 30 secs for 90 mins by HVA based fluorescence assay | B | 4.99 | pIC50 | 10300 | nM | IC50 | J Med Chem (2017) 60: 2006-2017 [PMID:28165241] |
| Farnesoid X receptor/Bile acid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2047] [GtoPdb: 603] [UniProtKB: Q96RI1] | ||||||||
| ChEMBL | Antagonist activity against human FXR transfected in HEK293T cells co-transfected with pCDNA-hFXR and pRL-TK incubated for 24 hrs by dual-luciferase reporter assay | B | 4.17 | pIC50 | 68220 | nM | IC50 | Eur J Med Chem (2024) 264: 115992-115992 [PMID:38043493] |
| GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] | ||||||||
| ChEMBL | Agonist activity at wild type human TGR5 expressed in HEK293 cells assessed as rise in intracellular cAMP level incubated for 16 hrs by luciferase reporter gene assay | F | 4.3 | pEC50 | 50500 | nM | EC50 | Eur J Med Chem (2015) 104: 57-72 [PMID:26435512] |
| ChEMBL | Agonist activity at human TGR5 expressed in CHO cells by luciferase assay | F | 4.52 | pEC50 | 30000 | nM | EC50 | J Med Chem (2008) 51: 1831-1841 [PMID:18307294] |
| Sodium/bile acid and sulphated solute cotransporter 2/Ileal sodium/bile acid cotransporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2778] [GtoPdb: 960] [UniProtKB: Q12908] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Taurocholate uptake in ASBT-expressing COS cells | F | 4.55 | pKi | 28000 | nM | Ki | Am J Physiol (1998) 274: G157-G169 [PMID:9458785] |
| sPLA2-1B/Phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4426] [GtoPdb: 1416] [UniProtKB: P04054] | ||||||||
| ChEMBL | Binding affinity to human pancreatic recombinant 1B PLA2 expressed in Escherichia coli by resonance energy transfer assay in presence of trimethyl-ammonium-diphenylhexatriene | B | 5 | pKd | 10000 | nM | Kd | J Nat Prod (2009) 72: 24-28 [PMID:19102680] |
ChEMBL data shown on this page come from version 36:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
