L-168,049 [Ligand Id: 3505] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL351772 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| glucagon receptor/Glucagon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871] | ||||||||
| ChEMBL | Antagonist activity at human glucagon receptor | B | 5.84 | pIC50 | 1442.12 | nM | IC50 | Med Chem Res (2013) null: 1-16 |
| ChEMBL | Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the human glucagon receptor (GGR) expressed on CHO cells in presence of Mg+2 | B | 6.77 | pIC50 | 170 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
| ChEMBL | Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2 | B | 8.15 | pIC50 | 7 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
| GtoPdb | - | - | 8.4 | pIC50 | 3.7 | nM | IC50 | J Biol Chem (1999) 274: 8694-7 [PMID:10085108] |
| glucagon receptor/Glucagon receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4773] [GtoPdb: 251] [UniProtKB: Q61606] | ||||||||
| ChEMBL | Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on CHO cells in presence of Mg+2 | B | 6.6 | pIC50 | 250 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
| ChEMBL | Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the murine glucagon receptor (GGR) expressed on CHO cells in absence of Mg+2 | B | 7.43 | pIC50 | 37 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
| mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539] | ||||||||
| ChEMBL | Inhibitory activity against p38-alpha kinase | B | 5.84 | pIC50 | 1440 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 641-646 [PMID:10201821] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
