L-168,049 [Ligand Id: 3505] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL351772
  • glucagon receptor/Glucagon receptor in Human [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871]
  • glucagon receptor/Glucagon receptor in Mouse [ChEMBL: CHEMBL4773] [GtoPdb: 251] [UniProtKB: Q61606]
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  • mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
glucagon receptor/Glucagon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871]
ChEMBL Antagonist activity at human glucagon receptor B 5.84 pIC50 1442.12 nM IC50 Med Chem Res (2013) null: 1-16
ChEMBL Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the human glucagon receptor (GGR) expressed on CHO cells in presence of Mg+2 B 6.77 pIC50 170 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 641-646 [PMID:10201821]
ChEMBL Binding affinity determined by reduction in binding of 125 I-glucagon to the human glucagon receptor expressed on CHO cells in absence of Mg+2 B 8.15 pIC50 7 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 641-646 [PMID:10201821]
GtoPdb - - 8.4 pIC50 3.7 nM IC50 J Biol Chem (1999) 274: 8694-7 [PMID:10085108]
glucagon receptor/Glucagon receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4773] [GtoPdb: 251] [UniProtKB: Q61606]
ChEMBL Binding affinity towards glucagon receptor determined by reduction in binding of 125 I-glucagon to the murine glucagon receptor (mGLUR) expressed on CHO cells in presence of Mg+2 B 6.6 pIC50 250 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 641-646 [PMID:10201821]
ChEMBL Binding affinity towards glucagon receptor determined by reduction in binding of [125I]glucagon to the murine glucagon receptor (GGR) expressed on CHO cells in absence of Mg+2 B 7.43 pIC50 37 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 641-646 [PMID:10201821]
mitogen-activated protein kinase 14/MAP kinase p38 alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL260] [GtoPdb: 1499] [UniProtKB: Q16539]
ChEMBL Inhibitory activity against p38-alpha kinase B 5.84 pIC50 1440 nM IC50 Bioorg. Med. Chem. Lett. (1999) 9: 641-646 [PMID:10201821]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]