fulvestrant   Click here for help

GtoPdb Ligand ID: 1015

Synonyms: Faslodex® | ICI 182,780 | ICI 182780 | ICI182780 | ZD-9238
Approved drug
fulvestrant is an approved drug (FDA (2002), EMA (2004))
Compound class: Synthetic organic
Comment: Fulvestrant is an estrogen receptor antagonist. It behaves as a selective estrogen receptor degrader (SERD). Fulvestrant binding triggers ERα's degradation by ubiquitination.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 15
Topological polar surface area 76.74
Molecular weight 606.32
XLogP 10.2
No. Lipinski's rules broken 2
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Isomeric SMILES O=S(CCCC(C(F)(F)F)(F)F)CCCCCCCCC[C@@H]1Cc2cc(O)ccc2[C@@H]2[C@@H]1[C@@H]1CC[C@@H]([C@]1(CC2)C)O
InChI InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (FDA (2002), EMA (2004))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
7712 fulvestrant
Synonyms Click here for help
Faslodex® | ICI 182,780 | ICI 182780 | ICI182780 | ZD-9238
Database Links Click here for help
Specialist databases
GPCRdb Ligand fulvestrant
Other databases
BindingDB Ligand 50169743
CAS Registry No. 129453-61-8
ChEMBL Ligand CHEMBL1358
DrugBank Ligand DB00947
DrugCentral Ligand 1255
GtoPdb PubChem SID 135650370
PubChem CID 104741
Search Google for chemical match using the InChIKey VWUXBMIQPBEWFH-WCCTWKNTSA-N
Search Google for chemicals with the same backbone VWUXBMIQPBEWFH
Search PubMed clinical trials fulvestrant
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UniChem Compound Search for chemical match using the InChIKey VWUXBMIQPBEWFH-WCCTWKNTSA-N
UniChem Connectivity Search for chemical match using the InChIKey VWUXBMIQPBEWFH-WCCTWKNTSA-N
Wikipedia Fulvestrant