ChEMBL ligand: CHEMBL12856 (Amcoral, Amrinone, C01CE01, Cartonic, Cordemcura, Inamrinone, NSC-759805, Vesistol, WIN 40680, WIN-40680, Wincoram)
aurora kinase B/Aurora kinase B/Inner centromere protein in Human [ChEMBL: CHEMBL3430907] [GtoPdb: 1937] [UniProtKB: Q96GD4, Q9NQS7] There should be some charts here, you may need to enable JavaScript!
TTK protein kinase/Dual specificity protein kinase TTK in Human [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] There should be some charts here, you may need to enable JavaScript!
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432] There should be some charts here, you may need to enable JavaScript!
phosphodiesterase 3B in Human [GtoPdb: 1299] [UniProtKB: Q13370] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
aurora kinase B/Aurora kinase B/Inner centromere protein in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430907] [GtoPdb: 1937] [UniProtKB: Q96GD4, Q9NQS7]
ChEMBL	Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in baculovirus expression system using fluorescence-labeled FL-Peptide 21 as substrate after 60 mins in presence of ATP by fluorescence assay based Cheng-Prusoff equation analysis	B	4.23	pKi	59300	nM	Ki	Bioorg Med Chem (2018) 26: 3021-3029 [PMID:29764757]
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
ChEMBL	Inhibition of full length human Mps1 using fluorescence-labeled H236 peptide as substrate after 60 to 90 mins in presence of ATP by fluorescence assay based Cheng-Prusoff equation analysis	B	4.09	pKi	80800	nM	Ki	Bioorg Med Chem (2018) 26: 3021-3029 [PMID:29764757]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL	Inhibition of full length N-terminal His-tagged Aurora A (unknown origin) using fluorescence-labeled FL-Peptide 21 as substrate after 60 mins in presence of ATP by fluorescence assay based Cheng-Prusoff equation analysis	B	3.4	pKi	393900	nM	Ki	Bioorg Med Chem (2018) 26: 3021-3029 [PMID:29764757]
phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432]
GtoPdb	Inhibition of PDE3 purified from human platelets, and therefore assumed to be the PDE3A subtype.	-	4.8	pIC50	16000	nM	IC50	J Med Chem (1989) 32: 342-50 [PMID:2536438]
phosphodiesterase 3B in Human [GtoPdb: 1299] [UniProtKB: Q13370]
GtoPdb	-	-	4.51	pIC50	31200	nM	IC50	Biochem Pharmacol (2000) 59: 347-56 [PMID:10644042]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]