inamrinone [Ligand Id: 7202] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL12856 (Amrinone, WIN-40680, Inocor, Inamrinone)
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  • TTK protein kinase/Dual specificity protein kinase TTK in Human [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
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  • aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
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  • phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432]
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  • phosphodiesterase 3B in Human [GtoPdb: 1299] [UniProtKB: Q13370]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
aurora kinase B/Aurora kinase B/Inner centromere protein in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430907] [GtoPdb: 1937] [UniProtKB: Q96GD4Q9NQS7]
ChEMBL Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in baculovirus expression system using fluorescence-labeled FL-Peptide 21 as substrate after 60 mins in presence of ATP by fluorescence assay based Cheng-Prusoff equation analysis B 4.23 pKi 59300 nM Ki Bioorg Med Chem (2018) 26: 3021-3029 [PMID:29764757]
TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981]
ChEMBL Inhibition of full length human Mps1 using fluorescence-labeled H236 peptide as substrate after 60 to 90 mins in presence of ATP by fluorescence assay based Cheng-Prusoff equation analysis B 4.09 pKi 80800 nM Ki Bioorg Med Chem (2018) 26: 3021-3029 [PMID:29764757]
aurora kinase A/Serine/threonine-protein kinase Aurora-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4722] [GtoPdb: 1936] [UniProtKB: O14965]
ChEMBL Inhibition of full length N-terminal His-tagged Aurora A (unknown origin) using fluorescence-labeled FL-Peptide 21 as substrate after 60 mins in presence of ATP by fluorescence assay based Cheng-Prusoff equation analysis B 3.4 pKi 393900 nM Ki Bioorg Med Chem (2018) 26: 3021-3029 [PMID:29764757]
phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432]
GtoPdb Inhibition of PDE3 purified from human platelets, and therefore assumed to be the PDE3A subtype. - 4.8 pIC50 16000 nM IC50 J. Med. Chem. (1989) 32: 342-50 [PMID:2536438]
phosphodiesterase 3B in Human [GtoPdb: 1299] [UniProtKB: Q13370]
GtoPdb - - 4.51 pIC50 31200 nM IC50 Biochem. Pharmacol. (2000) 59: 347-56 [PMID:10644042]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]