inamrinone [Ligand Id: 7202] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL12856 (Amcoral, Amrinone, C01CE01, Cartonic, Cordemcura, Inamrinone, Inocor, NSC-759805, Vesistol, WIN 40680, WIN-40680, Wincoram) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aurora kinase B/Aurora kinase B/Inner centromere protein in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3430907] [GtoPdb: 1937] [UniProtKB: Q96GD4, Q9NQS7] | ||||||||
| ChEMBL | Inhibition of human full length N-terminal GST-tagged Aurora B (1 to 344 end residues)/His-tagged INCENP (803 to 918 end residues) expressed in baculovirus expression system using fluorescence-labeled FL-Peptide 21 as substrate after 60 mins in presence of ATP by fluorescence assay based Cheng-Prusoff equation analysis | B | 4.23 | pKi | 59300 | nM | Ki | Bioorg Med Chem (2018) 26: 3021-3029 [PMID:29764757] |
| TTK protein kinase/Dual specificity protein kinase TTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3983] [GtoPdb: 2264] [UniProtKB: P33981] | ||||||||
| ChEMBL | Inhibition of full length human Mps1 using fluorescence-labeled H236 peptide as substrate after 60 to 90 mins in presence of ATP by fluorescence assay based Cheng-Prusoff equation analysis | B | 4.09 | pKi | 80800 | nM | Ki | Bioorg Med Chem (2018) 26: 3021-3029 [PMID:29764757] |
| phosphodiesterase 3A in Human [GtoPdb: 1298] [UniProtKB: Q14432] | ||||||||
| GtoPdb | Inhibition of PDE3 purified from human platelets, and therefore assumed to be the PDE3A subtype. | - | 4.8 | pIC50 | 16000 | nM | IC50 | J Med Chem (1989) 32: 342-50 [PMID:2536438] |
| phosphodiesterase 3B in Human [GtoPdb: 1299] [UniProtKB: Q13370] | ||||||||
| GtoPdb | - | - | 4.51 | pIC50 | 31200 | nM | IC50 | Biochem Pharmacol (2000) 59: 347-56 [PMID:10644042] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
