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Molecular properties generated using the CDK
|Compound class||Synthetic organic|
|PRN694 is a small molecule, covalent inhibitor somewhat selective for the TEC family kinases, IL-2-inducible T cell kinase (ITK) and TXK tyrosine kinase (also known as resting lymphocyte kinase or RLK) [2-3]. In vitro PRN694 is a potent inhibitor of Th1 and Th17 differentiation and cytokine production (IFN-γ production for Th1 and IL-17A for Th17), and in vivo PRN694 markedly reduces disease progression in a mouse colitis model . It is suggested that dual ITK and RLK inhibition may represent a novel therapeutic model for amelioration of Th1-mediated inflammatory diseases.
Mechanistically PRN694 inhibits kinase activity by binding irreversibly to cysteine residue 442 of ITK and 350 of RLK . A series of compounds including PRN694 is claimed in patent WO2014036016 . Example 29 is an enantiomer of PRN694 with one unspecified stereocenter.
|CAS Registry No.||1575818-46-0 (source: PubChem)|
|GtoPdb PubChem SID||318164804|
|Search Google for chemical match using the InChIKey||NXTKFBGDLDPFLB-PKOBYXMFSA-N|
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|Search UniChem for chemical match using the InChIKey||NXTKFBGDLDPFLB-PKOBYXMFSA-N|
|Search UniChem for chemicals with the same backbone||NXTKFBGDLDPFLB|