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ChEMBL ligand: CHEMBL284237 (Dizocilpine, MK-801) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] | ||||||||
ChEMBL | Inhibition of human BuChE using butyrylthiocholine iodide as substrate peincubated for 5 mins followed by substrate addition by DTNB-reagent based Ellman's method | B | 4.8 | pIC50 | 16000 | nM | IC50 | Eur J Med Chem (2021) 210: 113059-113059 [PMID:33310288] |
GABAA receptor π subunit/GABAA receptor β1 subunit/GABAA receptor δ subunit/GABAA receptor γ2 subunit/GABAA receptor α5 subunit/GABAA receptor α3 subunit/GABAA receptor γ1 subunit/GABAA receptor α2 subunit/GABAA receptor α4 subunit/GABAA receptor γ3 subunit/GABAA receptor α6 subunit/GABAA receptor α1 subunit/GABAA receptor β3 subunit/GABAA receptor β2 subunit/GABAA receptor ε subunit/GABA-A receptor; anion channel in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907607] [GtoPdb: 419, 410, 416, 414, 408, 406, 413, 405, 407, 415, 409, 404, 412, 411, 417] [UniProtKB: O09028, P15431, P18506, P18508, P19969, P20236, P23574, P23576, P28471, P28473, P30191, P62813, P63079, P63138, Q91ZM7, Q9ES14] | ||||||||
ChEMBL | In vitro inhibition of [3H]flunitrazepam displacement from GABA-A receptor | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (1993) 36: 2499-2507 [PMID:8355251] |
GABAA receptor α2 subunit/GABA receptor alpha-2 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL341] [GtoPdb: 405] [UniProtKB: P23576] | ||||||||
ChEMBL | Tested for in vitro inhibition of the displacement of [3H]mazindol from GABA receptor | B | 4.39 | pKi | 40867 | nM | Ki | J Med Chem (1993) 36: 2499-2507 [PMID:8355251] |
GluN2D/GluN3B/GluN1/GluN2A/GluN2B/GluN2C/GluN3A/Glutamate [NMDA] receptor in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2094124] [GtoPdb: 459, 461, 455, 456, 457, 458, 460] [UniProtKB: O15399, O60391, Q05586, Q12879, Q13224, Q14957, Q8TCU5] | ||||||||
ChEMBL | The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. | B | 8.17 | pKi | 6.8 | nM | Ki | J Med Chem (1998) 41: 393-400 [PMID:9464369] |
ChEMBL | The compound was tested for its ability to block PCP N-methyl-D-aspartate glutamate receptor at the PCP (phencyclidine) binding site in postmortem human frontal cortex. | B | 8.92 | pKi | 1.2 | nM | Ki | J Med Chem (1998) 41: 393-400 [PMID:9464369] |
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
ChEMBL | Binding affinity to rat brain NMDA receptor | B | 7.43 | pKd | 37.2 | nM | Kd | Bioorg Med Chem Lett (2015) 25: 5583-5588 [PMID:26525866] |
ChEMBL | Inhibition of N-methyl-D-aspartate glutamate receptor (NMDA receptor) from homogenized rat brain membrane, using [3H]-MK-801 as a radioligand | B | 6.68 | pKi | 211 | nM | Ki | J Med Chem (1990) 33: 789-808 [PMID:1688947] |
ChEMBL | Inhibition of N-methyl-D-aspartate glutamate receptor (NMDA receptor) from homogenized rat brain membrane, using [3H]-MK-801 as a radioligand | B | 7.25 | pKi | 56 | nM | Ki | J Med Chem (1990) 33: 789-808 [PMID:1688947] |
ChEMBL | Displacement of [3H]MK801 from NMDA receptor in rat brain neuronal membrane | B | 7.37 | pKi | 43 | nM | Ki | Bioorg Med Chem (2009) 17: 3456-3462 [PMID:19345586] |
ChEMBL | Inhibition of N-methyl-D-aspartate glutamate receptor (NMDA receptor) from homogenized rat brain membrane, using [3H]-MK-801 as a radioligand | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (1990) 33: 789-808 [PMID:1688947] |
ChEMBL | Displacement of [3H]MK801 from NMDA receptor in rat brain neuronal membrane | B | 8.05 | pKi | 9 | nM | Ki | Bioorg Med Chem (2009) 17: 3456-3462 [PMID:19345586] |
ChEMBL | Tested for in vitro inhibition of the displacement of [3H]TCP from NMDA receptor | B | 8.2 | pKi | 6.3 | nM | Ki | J Med Chem (1993) 36: 2499-2507 [PMID:8355251] |
ChEMBL | Tested for in vitro inhibition of the displacement of (+)-[3H]dizocilpine from NMDA receptor | B | 8.6 | pKi | 2.5 | nM | Ki | J Med Chem (1993) 36: 2499-2507 [PMID:8355251] |
ChEMBL | Displacement of [3H]TCP from NMDA receptor of rat brain membranes | B | 8.66 | pKi | 2.2 | nM | Ki | J Med Chem (1995) 38: 2483-2489 [PMID:7608913] |
ChEMBL | Binding affinity against phencyclidine (PCP) site of N-methyl-D-aspartate glutamate receptor from rat brain, using [3H]- TCP as radioligand. | B | 8.66 | pKi | 2.2 | nM | Ki | J Med Chem (1995) 38: 1826-1830 [PMID:7752207] |
ChEMBL | Binding affinity at TCP site of NMDA receptor was determined in rat brain homogenate by [3H]TCP displacement. | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (1995) 38: 21-27 [PMID:7837234] |
ChEMBL | In vitro radioligand binding assay for the N-methyl-D-aspartate glutamate receptor is performed using [3H]MK-801 and rat brain membrane suspensions | B | 8.77 | pKi | 1.7 | nM | Ki | J Med Chem (1997) 40: 4281-4289 [PMID:9435897] |
ChEMBL | In vitro binding to N-methyl-D-aspartate glutamate receptor using [3H]MK-801 (1 nM) and rat brain membrane suspensions | B | 8.89 | pKi | 1.3 | nM | Ki | Bioorg Med Chem Lett (2002) 12: 1583-1586 [PMID:12039567] |
ChEMBL | Evaluated for its affinity to bind PCP N-methyl-D-aspartate (NMDA) glutamate receptor in rat brain membrane using [3H]MK-801 as radioligand | B | 6.49 | pIC50 | 320 | nM | IC50 | J Med Chem (1990) 33: 1296-1305 [PMID:1691788] |
ChEMBL | Ability to inhibit glutamate induced accumulation of [45 [Ca2+]] in cultured rat cortical neurons | F | 7.24 | pIC50 | 58 | nM | IC50 | J Med Chem (1993) 36: 1977-1995 [PMID:8336337] |
ChEMBL | Evaluated for its affinity to bind PCP N-methyl-D-aspartate (NMDA) glutamate receptor in rat brain membrane using [3H]MK-801 as radioligand | B | 7.25 | pIC50 | 56 | nM | IC50 | J Med Chem (1990) 33: 1296-1305 [PMID:1691788] |
ChEMBL | Evaluated for its affinity to bind PCP N-methyl-D-aspartate (NMDA) glutamate receptor in rat brain membrane using [3H]MK-801 as radioligand | B | 7.44 | pIC50 | 36 | nM | IC50 | J Med Chem (1990) 33: 1296-1305 [PMID:1691788] |
ChEMBL | Binding affinity against PCP binding site associated with N-methyl-D-aspartate glutamate receptor from rat synaptic plasma membrane(SPM) determined using [3H]TCP as radioligand. | B | 8 | pIC50 | 10 | nM | IC50 | J Med Chem (1992) 35: 4135-4142 [PMID:1433216] |
ChEMBL | Inhibition against NMDA receptor by displacement of [3H]TCP binding from rat cortical membranes | B | 8.05 | pIC50 | 8.9 | nM | IC50 | J Med Chem (1994) 37: 3008-3015 [PMID:7932522] |
ChEMBL | The compound was tested in vitro for the displacement of the radioligand (+)-[3H]-MK-801 from synaptic plasma membranes from rat cortex against N-methyl-D-aspartate glutamate receptor | B | 8.25 | pIC50 | 5.6 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 2411-2415 [PMID:11078190] |
ChEMBL | Potency towards NMDA receptor measured as inhibition of (+)-[3-3H]MK-801 binding from synaptic plasma membrane obtained from rat cortex | B | 8.25 | pIC50 | 5.6 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 1915-1920 [PMID:10450953] |
ChEMBL | Inhibition of [3H]MK-801 binding to the PCP receptor site in guinea pig brain homogenate | B | 8.38 | pIC50 | 4.2 | nM | IC50 | J Med Chem (1993) 36: 1938-1946 [PMID:8101572] |
ChEMBL | Functional NMDA receptor antagonism expressed as inhibition of NMDA/glycine induced increase in cytosolic calcium in cultured rat cerebellar granule cells | F | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 1915-1920 [PMID:10450953] |
ChEMBL | The compound was tested in vitro for the inhibition of N-methyl-D-aspartate glutamate receptor in rat cerebellar granule cells (RCGCs). | B | 8.47 | pIC50 | 3.4 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 2411-2415 [PMID:11078190] |
ChEMBL | Inhibitory concentration of compound required to displace [3H]TCP 1-[ 1-(2-thienyl)cyclohexyl]piperidine in whole rat brain homogenate | B | 8.52 | pIC50 | 3 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 49-54 |
ChEMBL | Evaluated for their affinity at the PCP site for displacement of [3H]TCP in rat brain homogenates | B | 8.53 | pIC50 | 2.92 | nM | IC50 | J Med Chem (1993) 36: 654-670 [PMID:8459395] |
ChEMBL | Binding affinity towards PCP site of the NMDA receptor was measured by displacement of [3H]TPC in whole rat brain homogenate | B | 8.53 | pIC50 | 2.92 | nM | IC50 | J Med Chem (1993) 36: 1977-1995 [PMID:8336337] |
GluN1/GluN2B/Glutamate NMDA receptor; GRIN1/GRIN2B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907603] [GtoPdb: 455, 457] [UniProtKB: Q05586, Q13224] | ||||||||
ChEMBL | Antagonist activity at NR1/2B receptor expressed in xenopus laevis at pH 6.9 by two electrode voltage clamp method | F | 8.05 | pIC50 | 9 | nM | IC50 | J Med Chem (2008) 51: 3765-3776 [PMID:18540667] |
GluN2A/Glutamate [NMDA] receptor subunit epsilon 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1972] [GtoPdb: 456] [UniProtKB: Q12879] | ||||||||
ChEMBL | Antagonist activity at NR2A transfected in oocytes | F | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3399-3403 [PMID:21524576] |
GluN1/Glutamate (NMDA) receptor subunit zeta 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL330] [GtoPdb: 455] [UniProtKB: P35439] | ||||||||
ChEMBL | Ability to displace [3H]TCP from high affinity PCP N-methyl-D-aspartate glutamate receptor in rat brain homogenates in vitro was determined | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (1990) 33: 1069-1076 [PMID:2155320] |
ChEMBL | Ability to displace [3H]TCP from high affinity PCP N-methyl-D-aspartate glutamate receptor in rat brain homogenates in vitro was determined | B | 8.05 | pKi | 9 | nM | Ki | J Med Chem (1990) 33: 1069-1076 [PMID:2155320] |
ChEMBL | Ability to displace [3H]TCP from high affinity PCP N-methyl-D-aspartate glutamate receptor in rat brain homogenates in vitro was determined | B | 8.1 | pKi | 8 | nM | Ki | J Med Chem (1990) 33: 1069-1076 [PMID:2155320] |
Prolylcarboxypeptidase/Lysosomal Pro-X carboxypeptidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2335] [GtoPdb: 1584] [UniProtKB: P42785] | ||||||||
ChEMBL | Inhibition of [3H]-TCP binding to PCP receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellum | B | 8.28 | pIC50 | 5.3 | nM | IC50 | J Med Chem (1998) 41: 468-477 [PMID:9484497] |
ChEMBL | Inhibition of [3H]1-[1-(2-thienyl) piperidine ([3H]TCP) binding to phencyclidine receptor | B | 8.28 | pIC50 | 5.3 | nM | IC50 | J Med Chem (1989) 32: 1242-1248 [PMID:2542555] |
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] | ||||||||
ChEMBL | Tested for in vitro inhibition of the displacement of [3H]FOXY from mu opioid receptor | B | 4 | pKi | >100000 | nM | Ki | J Med Chem (1993) 36: 2499-2507 [PMID:8355251] |
M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
ChEMBL | Percent inhibition against Muscarinic acetylcholine receptor M5 at 1 uM | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2005) 48: 6887-6896 [PMID:16250647] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green assay | F | 5.1 | pIC50 | 7943.28 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 7G8 after 72 hrs by SYBR green assay | F | 5.4 | pIC50 | 3981.07 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum GB4 after 72 hrs by SYBR green assay | F | 5.6 | pIC50 | 2511.89 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5.7 | pIC50 | 1995.26 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] | ||||||||
ChEMBL | Inhibition of specific binding of [125I]PIPAG to sigma receptor in Guinea pig brain membranes | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
ChEMBL | Inhibition of specific binding of [3H]NANM of sigma receptor in Guinea pig brain membranes | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (1992) 35: 4683-4689 [PMID:1469697] |
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3602] [GtoPdb: 2552] [UniProtKB: Q9R0C9] | ||||||||
ChEMBL | Tested for in vitro inhibition of the displacement of (+)-[3H]pentazocine from sigma opioid receptor | B | 4.23 | pKi | 59167 | nM | Ki | J Med Chem (1993) 36: 2499-2507 [PMID:8355251] |
ChEMBL | Inhibition of [3H]NANM binding to sigma receptor obtained from tissue homogenate preparation of fresh whole rat brain minus cerebellum | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (1998) 41: 468-477 [PMID:9484497] |
ChEMBL | Inhibition of [3H]- N-allylnormetazocine ([3H]NANM) binding to sigma receptor | B | 5.77 | pIC50 | 1700 | nM | IC50 | J Med Chem (1989) 32: 1242-1248 [PMID:2542555] |
Kir3.2 in Mouse [GtoPdb: 435] [UniProtKB: P48542] | ||||||||
GtoPdb | - | - | 3.7 | pIC50 | - | - | - | Neuron (1996) 16: 941-52 [PMID:8630252] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]