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Target not currently curated in GtoImmuPdb

Target id: 1584

Nomenclature: Prolylcarboxypeptidase

Family: S28: Lysosomal Pro-Xaa carboxypeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 496 11q14 PRCP prolylcarboxypeptidase
Mouse - 491 7 E1 Prcp prolylcarboxypeptidase (angiotensinase C)
Rat - 493 1q32 Prcp prolylcarboxypeptidase
Previous and Unofficial Names Click here for help
Angiotensinase C | HUMPCP | lysosomal Pro-X carboxypeptidase | PCP | prolylcarboxypeptidase (angiotensinase C)
Database Links Click here for help
Specialist databases
MEROPS S28.001 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction Click here for help
EC Number:

Download all structure-activity data for this target as a CSV file go icon to follow link

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 35 [PMID: 24157366] Small molecule or natural product Primary target of this compound Hs Inhibition 10.1 pIC50 1
pIC50 10.1 (IC50 7.9x10-11 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
click arrow to show/hide IEA associations
GO:0002353 plasma kallikrein-kinin cascade IEA
Immuno Process:  Cellular signalling


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1. Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D et al.. (2013) Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett, 23 (23): 6228-33. [PMID:24157366]

How to cite this page

S28: Lysosomal Pro-Xaa carboxypeptidase: Prolylcarboxypeptidase. Last modified on 14/07/2015. Accessed on 07/02/2023. IUPHAR/BPS Guide to PHARMACOLOGY,