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Prolylcarboxypeptidase

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Target not currently curated in GtoImmuPdb

Target id: 1584

Nomenclature: Prolylcarboxypeptidase

Family: S28: Lysosomal Pro-Xaa carboxypeptidase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 496 11q14 PRCP prolylcarboxypeptidase
Mouse - 491 7 E1 Prcp prolylcarboxypeptidase (angiotensinase C)
Rat - 493 1q32 Prcp prolylcarboxypeptidase
Previous and Unofficial Names Click here for help
PCP | Angiotensinase C | HUMPCP | lysosomal Pro-X carboxypeptidase | prolylcarboxypeptidase (angiotensinase C)
Database Links Click here for help
Specialist databases
MEROPS S28.001 (Hs)
Other databases
Alphafold
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.16.2

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Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 35 [PMID: 24157366] Small molecule or natural product Primary target of this compound Hs Inhibition 10.1 pIC50 1
pIC50 10.1 (IC50 7.9x10-11 M) [1]
Immuno Process Associations
Immuno Process:  Inflammation
Immuno Process:  Cellular signalling

References

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1. Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D et al.. (2013) Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg Med Chem Lett, 23 (23): 6228-33. [PMID:24157366]

How to cite this page

S28: Lysosomal Pro-Xaa carboxypeptidase: Prolylcarboxypeptidase. Last modified on 14/07/2015. Accessed on 11/10/2024. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1584.