Prolylcarboxypeptidase | S28: Lysosomal Pro-Xaa carboxypeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

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Target not currently curated in GtoImmuPdb

Target id: 1584

Nomenclature: Prolylcarboxypeptidase

Family: S28: Lysosomal Pro-Xaa carboxypeptidase

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 496 11q14 PRCP prolylcarboxypeptidase
Mouse - 491 7 E2 Prcp prolylcarboxypeptidase (angiotensinase C)
Rat - 493 1q32 Prcp prolylcarboxypeptidase
Previous and Unofficial Names
Angiotensinase C | HUMPCP | lysosomal Pro-X carboxypeptidase | PCP | prolylcarboxypeptidase (angiotensinase C)
Database Links
Specialist databases
MEROPS S28.001 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 35 [PMID: 24157366] Hs Inhibition 10.1 pIC50 1
pIC50 10.1 (IC50 7.9x10-11 M) [1]


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1. Debenham JS, Graham TH, Verras A, Zhang Y, Clements MJ, Kuethe JT, Madsen-Duggan C, Liu W, Bhatt UR, Chen D et al.. (2013) Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors. Bioorg. Med. Chem. Lett., 23 (23): 6228-33. [PMID:24157366]

How to cite this page

S28: Lysosomal Pro-Xaa carboxypeptidase: Prolylcarboxypeptidase. Last modified on 14/07/2015. Accessed on 24/08/2019. IUPHAR/BPS Guide to PHARMACOLOGY,