Cdk2 inhibitor III [Ligand Id: 5948] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL80713
  • cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020P24864P24941]
  • This target only has 0 pki data point
1 CHEMBL80713_lig_chart_1 Cyclin-dependent kinase 2/cyclin E Human
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
  • This target only has 0 pki data point
2 CHEMBL80713_lig_chart_2 cyclin dependent kinase 1 Human
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094126] [GtoPdb: 1973] [UniProtKB: O96020P24864P24941]
GtoPdb CDK2/cyclin E complex - 6.3 pIC50 500 nM IC50 Bioorg. Med. Chem. Lett. (1997) 7: 2697-2702
ChEMBL Inhibitory concentration against cyclin dependent kinase-2 (CDK2)/Cyclin E B 6.3 pIC50 500 nM IC50 Bioorg. Med. Chem. Lett. (1997) 7: 2697-2702
cyclin dependent kinase 1 in Human [GtoPdb: 1961] [UniProtKB: P06493]
GtoPdb CDK1/cyclin B complex - 5.38 pIC50 4200 nM IC50 Proc. Natl. Acad. Sci. U.S.A. (2007) 104: 20523-8 [PMID:18077363]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]