dextrothyroxine [Ligand Id: 6951] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL559 (Dextrothyroxine, D-thyroxine) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
| ChEMBL | Ability to displace [3H]L-689560 from NMDA receptor glycine site in rat brain membranes | B | 6.48 | pIC50 | 330 | nM | IC50 | Bioorg Med Chem Lett (1996) 6: 1145-1150 |
| OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells | F | 6.57 | pKi | 270 | nM | Ki | Endocrinology (2004) 145: 4384-4391 [PMID:15166123] |
| Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3917] [GtoPdb: 589] [UniProtKB: P18113] | ||||||||
| ChEMBL | In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor | B | 5.6 | pIC50 | 2500 | nM | IC50 | J Med Chem (1995) 38: 695-707 [PMID:7861417] |
| ChEMBL | In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor | B | 7.46 | pIC50 | 35 | nM | IC50 | J Med Chem (1995) 38: 695-707 [PMID:7861417] |
| transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
| ChEMBL | Inhibition of transthyretin fibril formation at pH 4.4 | F | 5.14 | pIC50 | 7170 | nM | IC50 | J Med Chem (2007) 50: 5589-5599 [PMID:17948976] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
