dextrothyroxine [Ligand Id: 6951] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL559 (Thyroxine, D-thyroxine, Liotrix, Dextrothyroxine, Choloxin)
There should be some charts here, you may need to enable JavaScript!
  • OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5]
There should be some charts here, you may need to enable JavaScript!
  • Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Rat [ChEMBL: CHEMBL3917] [GtoPdb: 589] [UniProtKB: P18113]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455456457458459461460] [UniProtKB: P35439Q00959Q00960Q00961Q62645Q8VHN2Q9R1M7]
ChEMBL Ability to displace [3H]L-689560 from NMDA receptor glycine site in rat brain membranes B 6.48 pIC50 330 nM IC50 Bioorg. Med. Chem. Lett. (1996) 6: 1145-1150
OATP1C1/Solute carrier organic anion transporter family member 1C1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2073688] [GtoPdb: 1222] [UniProtKB: Q9ERB5]
ChEMBL TP_TRANSPORTER: inhibition of L-T4 uptake in Oatp14-expressing HEK293 cells F 6.57 pKi 270 nM Ki Endocrinology (2004) 145: 4384-4391 [PMID:15166123]
Thyroid hormone receptor-β/Thyroid hormone receptor beta-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3917] [GtoPdb: 589] [UniProtKB: P18113]
ChEMBL In vitro inhibition of bound [125I]L-T3 rat plasma membrane 3,5,3'' L-triiodothyronine receptor B 5.6 pIC50 2500 nM IC50 J. Med. Chem. (1995) 38: 695-707 [PMID:7861417]
ChEMBL In vitro inhibition of the bound [125I]L-T3 rat liver nuclear L-triiodothyronine receptor B 7.46 pIC50 35 nM IC50 J. Med. Chem. (1995) 38: 695-707 [PMID:7861417]
transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766]
ChEMBL Inhibition of transthyretin fibril formation at pH 4.4 F 5.14 pIC50 7170 nM IC50 J. Med. Chem. (2007) 50: 5589-5599 [PMID:17948976]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]