benazepril [Ligand Id: 6374] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL838 (Benazepril, Benazepril sandoz, Briem, C09AA07, CGS-14824A, Cibacene, Cibacen ws, Forteekor, Lotensin, Lotrel) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| ChEMBL | Inhibitory activity against angiotensin I converting enzyme (ACE) | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (2000) 43: 305-341 [PMID:10669559] |
| GtoPdb | - | - | 8.8 | pIC50 | 1.7 | nM | IC50 | J Med Chem (1985) 28: 1603-6 [PMID:2999394] |
| Angiotensin-converting enzyme in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4074] [UniProtKB: P12822] | ||||||||
| ChEMBL | Inhibition of rabbit lung ACE assessed as hydrolysis of hippuryl-histidyl-leucine to hippuric acid and histidyl-leucine after 30 mins | B | 6.67 | pIC50 | 212 | nM | IC50 | Bioorg Med Chem (2013) 21: 4485-4493 [PMID:23777825] |
| ChEMBL | Inhibition of rabbit lung ACE assessed as hippuryl-histidyl-leucine hydrolysis after 30 mins by colorimetric method | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2015) 23: 3526-3533 [PMID:25922179] |
| ChEMBL | Tested for 50% inhibition of Angiotensin converting enzyme(ACE) obtained from rabbit lung (in vitro) | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (1994) 37: 1823-1832 [PMID:8021921] |
| Angiotensin-converting enzyme in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2625] [GtoPdb: 1613] [UniProtKB: P47820] | ||||||||
| ChEMBL | In vitro inhibitory activity against Angiotensin I converting enzyme | B | 8.77 | pIC50 | 1.7 | nM | IC50 | J Med Chem (1985) 28: 1603-1606 [PMID:2999394] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
