BMS-561392 [Ligand Id: 6509] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL489100 (BMS-561392)
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  • MMP1/Matrix metalloproteinase-1 in Human [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
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  • MMP13/Matrix metalloproteinase 13 in Human [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
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  • MMP14/Matrix metalloproteinase 14 in Human [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
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  • MMP2/Matrix metalloproteinase-2 in Human [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
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  • MMP3/Matrix metalloproteinase 3 in Human [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
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  • MMP9/Matrix metalloproteinase 9 in Human [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ADAM10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5028] [GtoPdb: 1658] [UniProtKB: O14672]
ChEMBL Inhibition of ADAM10 (unknown origin) using fluorescent substrate by fluorescence-based FRET assay B 6.32 pIC50 480 nM IC50 MedChemComm (2011) 2: 966-972
ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536]
ChEMBL Inhibition of human catalytic domain of TACE assessed as inhibit the cleavage of the substrate by fluorescence-based FRET assay B 7.92 pIC50 12 nM IC50 MedChemComm (2011) 2: 966-972
GtoPdb - - 8.7 pIC50 2 nM IC50 Bioorg. Med. Chem. (2009) 17: 444-59 [PMID:19095454]
ChEMBL Inhibition of TACE B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. (2009) 17: 444-459 [PMID:19095454]
MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956]
ChEMBL Inhibition of MMP1 (unknown origin) by fluorescence-based FRET assay B 6.37 pIC50 429 nM IC50 MedChemComm (2011) 2: 966-972
MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452]
ChEMBL Inhibition of MMP13 (unknown origin) by fluorescence-based FRET assay B 6.34 pIC50 461 nM IC50 MedChemComm (2011) 2: 966-972
MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281]
ChEMBL Inhibition of MMP14 (unknown origin) by fluorescence-based FRET assay B 6.3 pIC50 499 nM IC50 MedChemComm (2011) 2: 966-972
MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253]
ChEMBL Inhibition of MMP2 (unknown origin) by fluorescence-based FRET assay B 6.32 pIC50 482 nM IC50 MedChemComm (2011) 2: 966-972
MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254]
ChEMBL Inhibition of MMP3 (unknown origin) by fluorescence-based FRET assay B 6.55 pIC50 285 nM IC50 MedChemComm (2011) 2: 966-972
MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237]
ChEMBL Inhibition of MMP7 (unknown origin) by fluorescence-based FRET assay B 6.33 pIC50 466 nM IC50 MedChemComm (2011) 2: 966-972
MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894]
ChEMBL Inhibition of MMP8 (unknown origin) by fluorescence-based FRET assay B 6.52 pIC50 299 nM IC50 MedChemComm (2011) 2: 966-972
MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780]
ChEMBL Inhibition of MMP9 (unknown origin) by fluorescence-based FRET assay B 6.41 pIC50 389 nM IC50 MedChemComm (2011) 2: 966-972

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]