silmitasertib [Ligand Id: 8126] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1230165 (Silmitasertib, CX 4945, CX-4945, Cx-4945, CX4945)
  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
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  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
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  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/Casein kinase II alpha`/ beta in Human [ChEMBL: CHEMBL3883328] [GtoPdb: 15501551] [UniProtKB: P19784P67870]
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  • casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784]
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  • casein kinase 2, beta polypeptide subunit/Casein kinase II beta in Human [ChEMBL: CHEMBL2358] [GtoPdb: 1551] [UniProtKB: P67870]
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  • death associated protein kinase 3/Death-associated protein kinase 3 in Human [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
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  • CDC like kinase 2/Dual specificity protein kinase CLK2 in Human [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
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  • CDC like kinase 3/Dual specificity protein kinase CLK3 in Human [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
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  • dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
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  • dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
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  • homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422]
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
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  • Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
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  • TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
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  • fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
ChEMBL Inhibition of recombinant human CK2 holoenzyme using RRRDDDSDDD as substrate measured after 20 mins at 30 degC by radiometric kinase assay in presence of [gamma-32P]ATP B 9.42 pKi 0.38 nM Ki Eur. J. Med. Chem. (2016) 115: 148-160 [PMID:27017545]
ChEMBL Inhibition of CK2 in human Jurkat cells assessed as inhibition of [gamma33P]ATP incorporation into substrate by luminescence assay B 7 pIC50 100 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
ChEMBL Inhibition of human recombinant CK2 expressed in Escherichia coli BL21(DE3) using RRRDDDSDDD as substrate after 15 mins by capillary electrophoretic analysis B 8.43 pIC50 3.7 nM IC50 Eur. J. Med. Chem. (2013) 65: 205-222 [PMID:23711832]
ChEMBL Inhibition of human recombinant CK2a1/CK2b holoenzyme expressed in Escherichia coli BL21(DE3) pre-incubated for 10 mins before substrate addition by capillary electrophoresis based assay B 8.43 pIC50 3.7 nM IC50 J. Med. Chem. (2015) 58: 265-277 [PMID:25272055]
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2011) 54: 635-54 [PMID:21174434]
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2011) 54: 635-54 [PMID:21174434]
ChEMBL Inhibition of human recombinant CK2 assessed as inhibition of [gamma33P]ATP incorporation into substrate by luminescence assay B 9 pIC50 1 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
ChEMBL Inhibition of human recombinant CK2 using RRRDDDSDDD as substrate by radiometric assay in the presence of 15 uM [ATP] B 9 pIC50 1 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6687-6692 [PMID:21982499]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL Inhibition of ARC-1504 binding to CK2alpha (unknown origin) (1 to 335 residues) measured after 15 mins by fluorescence anisotropic method B 9.25 pKd 0.56 nM Kd Bioorg Med Chem (2017) 25: 2277-2284 [PMID:28274673]
ChEMBL Inhibition of ARC-1504 binding to CK2alpha (unknown origin) (1 to 335 residues) measured after 15 mins by fluorescence anisotropic method B 9.25 pKd 0.56 nM Kd Bioorg Med Chem (2017) 25: 2277-2284 [PMID:28274673]
ChEMBL Inhibition of CK2alpha (unknown origin) using RRRADDSDDDDD as substrate in presence of [gamma33P]-ATP by autoradiography B 9.42 pKi 0.38 nM Ki Eur J Med Chem (2019) 181: 111581-111581 [PMID:31400711]
ChEMBL Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assay B 5.7 pIC50 2000 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of CK2alpha (unknown origin) assessed as reduction in GST-Six1 phosphorylation in presence of ATP by radiometric kinase assay B 5.7 pIC50 2000 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assay B 5.7 pIC50 2000 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of CK2alpha (unknown origin) assessed as reduction in nucleolin phosphorylation in presence of ATP by radiometric kinase assay B 5.7 pIC50 2000 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Modulation of Endogenous Assay: The human leukemia Jurkat T-cell line was maintained in RPMI 1640 (Cambrex) supplemented with 10% fetal calf serum and 50 ng/ml Geutamycin. Before treatment cells were washed, resuspended at a density of about 106 cells/milliliter in medium containing 1% fetal calf serum and incubated in the presence of indicated mounts of drug for two hours. Cells were recovered by centrifugation, lysed using a hypotonic buffer (20 mM Tris/HCl pH 7.4; 2 mM EDTA; 5 mM EGTA; 10 mM mercaptoethanol; 10 mM NaF; 1 uM Okadaic acid; 10% v/v glycerol; 0.05% NP-40; 1% Protease Inhibitor Cocktail) and protein from the cleared lysate was diluted to 1 microgram per microliter in Assay Dilution Buffer (ADB; 20 mM MOPS, pH 7.2, 25 mM β-glycerolphosphate, 5 mM EGTA, 1 mM sodium orthovanadate and 1 mM dithiothreitol). To 20 microliters of diluted protein was added 10 microliters of substrate peptide (RRRDDDSDDD, dissolved in ADB at a concentration of 1 mM) and 10 microliters of PKA Inhibitor cocktail (Upstate). B 7 pIC50 100 nM IC50 US-9062043-B2. Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators (2015)
ChEMBL Inhibition of CK2alpha1 (unknown origin) using casein as substrate in presence of [gamma33P]ATP B 7 pIC50 100 nM IC50 Eur. J. Med. Chem. (2014) 78: 217-224 [PMID:24681986]
ChEMBL Inhibition of CK2alpha (unknown origin) (1 to 335 residues) using 5-TAMRA-RADDSDDDDD as substrate after 30 mins by fluorescence imaging method B 7.7 pIC50 20 nM IC50 Bioorg Med Chem (2017) 25: 2277-2284 [PMID:28274673]
ChEMBL Inhibition of GST-tagged human CK2alpha (1 to 391 residues) using CK2tide as substrate incubated for 1 hr by off-chip mobility shift assay B 7.72 pIC50 19 nM IC50 Bioorg. Med. Chem. (2016) 24: 1136-1141 [PMID:26850376]
ChEMBL Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay B 7.83 pIC50 14.7 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of CK2alpha (unknown origin) (2 to 329 residues) expressed in Escherichia coli BL21 (DE3) using RRRADDSDDDD substrate incubated for 40 mins by ADP-Glo kinase assay B 7.83 pIC50 14.7 nM IC50 Bioorg Med Chem (2018) 26: 3016-3020 [PMID:29759799]
ChEMBL Inhibition of recombinant human GST-tagged CK2alpha in presence of ATP by radiometric kinase assay B 7.83 pIC50 14.7 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate and [gamma-33P]ATP by scintillation counting method B 7.85 pIC50 14 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human CK2alpha using RRRDDDSDDD substrate and [gamma-33P]ATP by scintillation counting method B 7.85 pIC50 14 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human full length N-terminal His6-tagged CK2alpha expressed in Sf21 insect cells using CK2tide as substrate treated for 20 mins measured after 90 mins in presence of MgCl2 by caliper mobility shift assay B 8.52 pIC50 <3 nM IC50 Bioorg Med Chem Lett (2018) 28: 1336-1341 [PMID:29559278]
ChEMBL In Vitro Cell-Free Assay: Test compounds in aqueous solution were added at a volume of 10 microliters, to a reaction mixture comprising 10 microliters Assay Dilution Buffer (ADB; 20 mM MOPS, pH 7.2, 25 mM beta-glycerolphosphate, 5 mM EGTA, 1 mM sodium orthovanadate and 1 mM dithiothreitol), 10 microliters of substrate peptide (RRRDDDSDDD, dissolved in ADB at a concentration of 1 mM), 10 microliters of recombinant human CK2 (25 ng dissolved in ADB; Upstate). Reactions were initiated by the addition of 10 microliters of ATP Solution (90% 75 mM MgCl2, 75 micromolar ATP dissolved in ADB; 10% [gamma-33P]ATP (stock 1 mCi/100 ul; 3000 Ci/mmol (Perkin Elmer) and maintained for 10 minutes at 30 degrees C. The reactions were quenched with 100 microliters of 0.75% phosphoric acid, then transferred to and filtered through a phosphocellulose filter plate (Millipore). After washing each well 5 times with 0.75% phosphoric acid, the plate was dried under vacuum for 5 min. B 8.7 pIC50 2 nM IC50 US-9062043-B2. Fused tricyclic compounds as serine-threonine protein kinase and PARP modulators (2015)
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2011) 54: 635-54 [PMID:21174434]
ChEMBL Inhibition of human recombinant CK2alpha by radiometric assay B 9 pIC50 1 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
ChEMBL Inhibition of human recombinant CK2alpha at enzyme-substrate complex by radiometric assay B 9 pIC50 1 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
ChEMBL Displacement of 5-TAMRA-labeled ARC-1530 from CK2alpha (unknown origin) (1 to 335 residues) after 15 to 60 mins by luminescence assay B 9.3 pIC50 0.5 nM IC50 Bioorg Med Chem (2018) 26: 5062-5068 [PMID:30217463]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/Casein kinase II alpha`/ beta in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3883328] [GtoPdb: 15501551] [UniProtKB: P19784P67870]
ChEMBL Inhibition of human recombinant CK2alpha/CK2beta using RRRDDDSDDD peptide as substrate by radiometric assay B 9.66 pKi 0.22 nM Ki Bioorg. Med. Chem. Lett. (2012) 22: 45-48 [PMID:22169261]
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2011) 54: 635-54 [PMID:21174434]
ChEMBL Inhibition of human recombinant CK2alpha/CK2beta using RRRDDDSDDD peptide as substrate by radiometric assay B 9.52 pIC50 0.3 nM IC50 Bioorg. Med. Chem. Lett. (2012) 22: 45-48 [PMID:22169261]
casein kinase 2, alpha prime polypeptide subunit/Casein kinase II alpha (prime) in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4070] [GtoPdb: 1550] [UniProtKB: P19784]
ChEMBL Inhibition of GST-tagged human CK2alpha' (1 to 350 residues) using CK2tide as substrate incubated for 1 hr by off-chip mobility shift assay B 7.96 pIC50 11 nM IC50 Bioorg. Med. Chem. (2016) 24: 1136-1141 [PMID:26850376]
GtoPdb - - 9 pIC50 1 nM IC50 J Med Chem (2011) 54: 635-54 [PMID:21174434]
casein kinase 2, beta polypeptide subunit/Casein kinase II beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2358] [GtoPdb: 1551] [UniProtKB: P67870]
ChEMBL Inhibition of CK2beta autophosphorylation (unknown origin) in presence of ATP by radiometric kinase assay B 5.7 pIC50 2000 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of CK2beta autophosphorylation (unknown origin) in presence of ATP by radiometric kinase assay B 5.7 pIC50 2000 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067P06493P14635Q8WWL7]
ChEMBL Inhibition of human recombinant CDK1/Cyclin B by radiometric assay B 7.25 pIC50 56 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
cyclin dependent kinase 2/Cyclin-dependent kinase 2/cyclin E1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907605] [GtoPdb: 1973] [UniProtKB: P24864P24941]
ChEMBL Inhibition of CDK2/cyclin E (unknown origin) expressed in Sf9 cells using histone H1 as substrate in presence of [gamma33P]ATP B 5.74 pIC50 1800 nM IC50 Eur. J. Med. Chem. (2014) 78: 217-224 [PMID:24681986]
death associated protein kinase 3/Death-associated protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2468] [GtoPdb: 2004] [UniProtKB: O43293]
ChEMBL Inhibition of human recombinant DAPK3 by radiometric assay B 7.77 pIC50 17 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
GtoPdb - - 7.77 pIC50 17 nM IC50 J Med Chem (2011) 54: 635-54 [PMID:21174434]
CDC like kinase 2/Dual specificity protein kinase CLK2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4225] [GtoPdb: 1991] [UniProtKB: P49760]
ChEMBL Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillation counting method B 8.4 pIC50 4 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human CLK2 in presence of ATP by radiometric filter-binding assay B 8.4 pIC50 4 nM IC50 J Med Chem (2019) 62: 1803-1816 [PMID:30689953]
ChEMBL Inhibition of N-terminal GST-tagged human CLK2 (138 to end residues) using SR-rich substrate and [gamma-33P]ATP incubated for 40 mins by scintillation counting method B 8.4 pIC50 4 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human CLK2 in presence of ATP by radiometric filter-binding assay B 8.4 pIC50 4 nM IC50 J Med Chem (2019) 62: 1803-1816 [PMID:30689953]
ChEMBL Inhibition of CLK2 (unknown origin) B 8.42 pIC50 3.8 nM IC50 Bioorg Med Chem (2018) 26: 3016-3020 [PMID:29759799]
CDC like kinase 3/Dual specificity protein kinase CLK3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4226] [GtoPdb: 1992] [UniProtKB: P49761]
ChEMBL Inhibition of human recombinant CLK3 by radiometric assay B 7.39 pIC50 41 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
dual specificity tyrosine phosphorylation regulated kinase 1A/Dual-specificity tyrosine-phosphorylation regulated kinase 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2292] [GtoPdb: 2009] [UniProtKB: Q13627]
ChEMBL Inhibition of recombinant human DYRK1A by radiometric filter-binding assay B 8.17 pIC50 6.8 nM IC50 J Med Chem (2018) 61: 9791-9810 [PMID:29985601]
ChEMBL Inhibition of human recombinant DyrK1a by fluorescence-based immunoassay B 8.17 pIC50 6.8 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human DYRK1A in presence of ATP by radiometric filter-binding assay B 8.17 pIC50 6.8 nM IC50 J Med Chem (2019) 62: 1803-1816 [PMID:30689953]
ChEMBL Inhibition of human recombinant DyrK1a by fluorescence-based immunoassay B 8.17 pIC50 6.8 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human DYRK1A in presence of ATP by radiometric filter-binding assay B 8.17 pIC50 6.8 nM IC50 J Med Chem (2019) 62: 1803-1816 [PMID:30689953]
dual specificity tyrosine phosphorylation regulated kinase 1B/Dual specificity tyrosine-phosphorylation-regulated kinase 1B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5543] [GtoPdb: 2010] [UniProtKB: Q9Y463]
ChEMBL Inhibition of recombinant human DYRK1B by radiometric filter-binding assay B 8.19 pIC50 6.4 nM IC50 J Med Chem (2018) 61: 9791-9810 [PMID:29985601]
ChEMBL Inhibition of human recombinant DyrK1b by fluorescence-based immunoassay B 8.19 pIC50 6.4 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human DYRK1B in presence of ATP by radiometric filter-binding assay B 8.19 pIC50 6.4 nM IC50 J Med Chem (2019) 62: 1803-1816 [PMID:30689953]
ChEMBL Inhibition of human recombinant DyrK1b by fluorescence-based immunoassay B 8.19 pIC50 6.4 nM IC50 J Med Chem (2019) 62: 1817-1836 [PMID:30689946]
ChEMBL Inhibition of recombinant human DYRK1B in presence of ATP by radiometric filter-binding assay B 8.19 pIC50 6.4 nM IC50 J Med Chem (2019) 62: 1803-1816 [PMID:30689953]
homeodomain interacting protein kinase 3/Homeodomain-interacting protein kinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4577] [GtoPdb: 2035] [UniProtKB: Q9H422]
ChEMBL Inhibition of human recombinant HIPK3 by radiometric assay B 7.35 pIC50 45 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
GtoPdb - - 7.35 pIC50 45 nM IC50 J Med Chem (2011) 54: 635-54 [PMID:21174434]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
GtoPdb - - 6.67 pIC50 216 nM IC50 Biochemistry (2011) 50: 8478-88 [PMID:21870818]
ChEMBL Inhibition of human recombinant Pim1 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 30 uM [ATP] B 7.32 pIC50 48 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6687-6692 [PMID:21982499]
ChEMBL Inhibition of human recombinant PIM1 by radiometric assay B 7.34 pIC50 46 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
Pim-2 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523] [GtoPdb: 2159] [UniProtKB: Q9P1W9]
ChEMBL Inhibition of human recombinant Pim2 using RSRHSSYPAGT as substrate by radiometric assay in the presence of 5 uM [ATP] B 6.73 pIC50 186 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 6687-6692 [PMID:21982499]
TANK binding kinase 1/Serine/threonine-protein kinase TBK1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5408] [GtoPdb: 2237] [UniProtKB: Q9UHD2]
ChEMBL Inhibition of human recombinant TBK1 by radiometric assay B 7.46 pIC50 35 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]
fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888]
ChEMBL Inhibition of human recombinant FLT3 by radiometric assay B 7.26 pIC50 55 nM IC50 J. Med. Chem. (2011) 54: 635-654 [PMID:21174434]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]