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ChEMBL ligand: CHEMBL3286796 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
ChEMBL | Binding affinity to EP1 receptor (unknown origin) | B | 5.89 | pKi | 1300 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
ChEMBL | Binding affinity to EP2 receptor (unknown origin) by competitive binding assay | B | 8.77 | pKi | 1.7 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
ChEMBL | Agonist activity at EP2 receptor (unknown origin) by functional assay | B | 8.74 | pEC50 | 1.8 | nM | EC50 | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
EP2 receptor in Mouse [GtoPdb: 341] [UniProtKB: Q62053] | ||||||||
GtoPdb | - | - | 8.5 | pKi | - | - | - | Endocrinology (2000) 141: 1554-9 [PMID:10746663] |
EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
ChEMBL | Binding affinity to EP3 receptor (unknown origin) | B | 5.57 | pKi | 2700 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
ChEMBL | Binding affinity to EP4 receptor (unknown origin) | B | 5.64 | pKi | 2300 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
ChEMBL | Binding affinity to prostanoid IP receptor (unknown origin) | B | 5 | pKi | 10000 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]