bederocin [Ligand Id: 10764] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1631216 (Bederocin, REP 8839, REP-8839, REP8839)
  • Methionyl-tRNA synthetase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [ChEMBL: CHEMBL1641340] [UniProtKB: P43828]
  • Methionyl-tRNA synthetase in Staphylococcus aureus subsp. aureus MW2 [ChEMBL: CHEMBL5372] [UniProtKB: Q8NY00]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Methionyl-tRNA synthetase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641340] [UniProtKB: P43828]
ChEMBL Inhibition of Haemophilus influenzae MetRS B 6.65 pKi 225 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
Methionyl-tRNA synthetase in Staphylococcus aureus subsp. aureus MW2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5372] [UniProtKB: Q8NY00]
ChEMBL Inhibition of Staphylococcus aureus MetRS G54A A64P mutant B 5.72 pKi 1900 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N G54S mutant B 6.05 pKi 900 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N I238F mutant B 6.46 pKi 350 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS G54S mutant B 7.07 pKi 85 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N A247E mutant B 7.22 pKi 60 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N V242F mutant B 7.82 pKi 15 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS G223C mutant B 9.29 pKi 0.51 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS V108M mutant B 9.96 pKi 0.11 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N mutant B 10.1 pKi 0.08 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS A247E mutant B 10.22 pKi 0.06 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS L213W mutant B 10.4 pKi 0.04 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]