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ChEMBL ligand: CHEMBL1631216 (Bederocin, REP 8839, REP-8839, REP8839) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Methionyl-tRNA synthetase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641340] [UniProtKB: P43828] | ||||||||
ChEMBL | Inhibition of Haemophilus influenzae MetRS | B | 6.65 | pKi | 225 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
Methionyl-tRNA synthetase in Staphylococcus aureus subsp. aureus MW2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5372] [UniProtKB: Q8NY00] | ||||||||
ChEMBL | Inhibition of Staphylococcus aureus MetRS G54A A64P mutant | B | 5.72 | pKi | 1900 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS I57N G54S mutant | B | 6.05 | pKi | 900 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS I57N I238F mutant | B | 6.46 | pKi | 350 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS G54S mutant | B | 7.07 | pKi | 85 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS I57N A247E mutant | B | 7.22 | pKi | 60 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS I57N V242F mutant | B | 7.82 | pKi | 15 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS G223C mutant | B | 9.29 | pKi | 0.51 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS V108M mutant | B | 9.96 | pKi | 0.11 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS I57N mutant | B | 10.1 | pKi | 0.08 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS A247E mutant | B | 10.22 | pKi | 0.06 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL | Inhibition of Staphylococcus aureus MetRS L213W mutant | B | 10.4 | pKi | 0.04 | nM | Ki | Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]