bederocin [Ligand Id: 10764] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1631216 (Bederocin, Bederocina, Bederocine, REP 8839, REP-8839, REP8839)
  • Methionyl-tRNA synthetase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) [ChEMBL: CHEMBL1641340] [UniProtKB: P43828]
  • Methionyl-tRNA synthetase in Staphylococcus aureus subsp. aureus MW2 [ChEMBL: CHEMBL5372] [UniProtKB: Q8NY00]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Methionyl-tRNA synthetase in Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641340] [UniProtKB: P43828]
ChEMBL Inhibition of Haemophilus influenzae MetRS B 6.65 pKi 225 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
Methionyl-tRNA synthetase in Staphylococcus aureus subsp. aureus MW2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5372] [UniProtKB: Q8NY00]
ChEMBL Inhibition of Staphylococcus aureus MetRS G54A A64P mutant B 5.72 pKi 1900 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N G54S mutant B 6.05 pKi 900 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N I238F mutant B 6.46 pKi 350 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS G54S mutant B 7.07 pKi 85 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N A247E mutant B 7.22 pKi 60 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N V242F mutant B 7.82 pKi 15 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS G223C mutant B 9.29 pKi 0.51 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS V108M mutant B 9.96 pKi 0.11 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS I57N mutant B 10.1 pKi 0.08 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS A247E mutant B 10.22 pKi 0.06 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]
ChEMBL Inhibition of Staphylococcus aureus MetRS L213W mutant B 10.4 pKi 0.04 nM Ki Antimicrob Agents Chemother (2009) 53: 86-94 [PMID:19015366]

ChEMBL data shown on this page come from version 35:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]