IL-22   Click here for help

GtoPdb Ligand ID: 4988

Synonyms: cytokine Zcyto18 | interleukin-22
Immunopharmacology Ligand
Comment: IL-22 is an IL-10 superfamily type II cytokine which plays a key role during inflammatory responses, and has potent neutrophil chemoattractant activity. It is regulated in part by IL-23. IL-22 has been demonstrated to play an important protective function in the gut where it promotes anti-microbial peptide expression. Via induction of intestinal epithelial stem cell proliferation, IL-22 is involved in gut barrier recovery after acute injury [2]. Conversely, IL-22 has also been implicated as a driving factor in chronic gut pathologies [5].
Species: Human
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Classification Click here for help
Compound class Endogenous peptide in human, mouse or rat
Ligand families/groups Interleukins
Synonyms Click here for help
cytokine Zcyto18 | interleukin-22
Gene/Precursor Click here for help
Gene symbol Gene name Species Precursor protein name Synonyms
IL22 interleukin 22 Human prepro-interleukin-22 IL-10-related T-cell-derived inducible factor, IL-21, IL-22, IL-D110, IL-TIF, ILTIF, MGC79382, MGC79384, TIFa, TIFIL-23, zcyto18
Database Links Click here for help
Ensembl Gene ENSG00000127318 (Hs)
GtoPdb PubChem SID 178101685
Human Protein Atlas ENSG00000127318 (Hs)
UniProtKB Q9GZX6 (Hs)
Wikipedia Interleukin_22