eptifibatide [Ligand Id: 6585] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1174 (Eptifibatide, Integrilin)
  • integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human [ChEMBL: CHEMBL2093869] [GtoPdb: 24572441] [UniProtKB: P05106P08514]
  • This target only has 0 pki data point
  • 0
1 CHEMBL1174_lig_chart_1 Integrin alpha-IIb/beta-3 Human
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  • integrin αIIbβ3 in Human [GtoPdb: 2579]
  • This target only has 0 pki data point
  • 0
2 CHEMBL1174_lig_chart_2 integrin αIIbβ3 Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
integrin, beta 3 subunit (platelet glycoprotein IIIa, antigen CD61)/integrin, alpha IIb subunit (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)/Integrin alpha-IIb/beta-3 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2093869] [GtoPdb: 24572441] [UniProtKB: P05106P08514]
ChEMBL Inhibition of fibrinogen binding to alpha IIb beta-3 integrin using thrombin inhibitor PPACK as anticoagulant F 6.24 pIC50 570 nM IC50 J. Med. Chem. (2000) 43: 3453-3473 [PMID:10999999]
ChEMBL Inhibition of human platelet aggregation collected with sodium citrate as anticoagulant F 6.85 pIC50 140 nM IC50 J. Med. Chem. (2000) 43: 3453-3473 [PMID:10999999]
integrin αIIbβ3 in Human [GtoPdb: 2579]
GtoPdb inhibition of human platelet aggregation. The IC50 varies according to the anti-coagulant used during blood collection. - 6.85 pIC50 140 nM IC50 J Med Chem (2000) 43: 3453-73 [PMID:10999999]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]