CPPZ [Ligand Id: 6416] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1289113 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| mGlu5 receptor/Metabotropic glutamate receptor 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3227] [GtoPdb: 293] [UniProtKB: P41594] | ||||||||
| ChEMBL | Displacement of [3H]-MPEP from human mGluR5 | B | 5.63 | pKi | 2370 | nM | Ki | Bioorg Med Chem Lett (2010) 20: 7381-7384 [PMID:21067920] |
| ChEMBL | Positive allosteric modulation of human mGluR5 expressed in HEK293 cells assessed as Ca2+ influx by FLIPR assay | F | 6.26 | pEC50 | 550 | nM | EC50 | Bioorg Med Chem Lett (2010) 20: 7381-7384 [PMID:21067920] |
| ChEMBL | Positive allosteric modulation of human mGluR5 over-expressed in HEK293 cells | B | 6.26 | pEC50 | 550 | nM | EC50 | J Med Chem (2013) 56: 7976-7996 [PMID:24050755] |
| GtoPdb | - | - | 6.3 | pEC50 | 500 | nM | EC50 | Eur J Pharmacol (2011) 659: 146-54 [PMID:21335002] |
| mGlu5 receptor in Rat [GtoPdb: 293] [UniProtKB: P31424] | ||||||||
| GtoPdb | - | - | 5.51 | pKi | 3100 | nM | Ki | Eur J Pharmacol (2011) 659: 146-54 [PMID:21335002] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
