Synonyms: example 8 [US20210047309] | GBT-021601 | GBT-601 | GBT021601
Compound class:
Synthetic organic
Comment: Osivelotor (GBT021601; Global Blood Therapeutics) is a clinical lead for the treatment of sickle cell disease. It stablilises sickle haemoglobin (HbS) in its oxygenated state which inhibits its polymerisation (the underlying cause of erythrocyte sickling) [3]. Based on preclinical studies osivelotor is proposed as an oral drug to reduce vaso-occlusive crises in people with sickle cell disease [1].
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Classification | |
Compound class | Synthetic organic |
IUPAC Name |
2-hydroxy-6-[[(3S)-4-[2-(2-hydroxyethyl)pyridine-3-carbonyl]morpholin-3-yl]methoxy]benzaldehyde |
International Nonproprietary Names | |
INN number | INN |
12553 | osivelotor |
Synonyms |
example 8 [US20210047309] | GBT-021601 | GBT-601 | GBT021601 |
Database Links | |
GtoPdb PubChem SID | 483123404 |
PubChem CID | 146567655 |
RCSB PDB Ligand | OHF |
Search Google for chemical match using the InChIKey | NIWBSQAKKNNWBT-AWEZNQCLSA-N |
Search Google for chemicals with the same backbone | NIWBSQAKKNNWBT |
Search PubMed clinical trials | osivelotor |
Search PubMed titles | osivelotor |
Search PubMed titles/abstracts | osivelotor |
UniChem Compound Search for chemical match using the InChIKey | NIWBSQAKKNNWBT-AWEZNQCLSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | NIWBSQAKKNNWBT-AWEZNQCLSA-N |