hGCGR antagonist [Ligand Id: 1148] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL179281 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| glucagon receptor/Glucagon receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1985] [GtoPdb: 251] [UniProtKB: P47871] | ||||||||
| ChEMBL | Inhibitory concentration towards binding of [125I]glucagon to the human glucagon receptor expressed in CHO cells | B | 6.74 | pIC50 | 181 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1401-1405 [PMID:15713396] |
| ChEMBL | Inhibition of glucagon induced cAMP accumulation in human glucagon receptor transfected CHO cells | F | 6.89 | pIC50 | 129 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1401-1405 [PMID:15713396] |
| GtoPdb | - | - | 7.1 | pIC50 | - | - | - | Diabetes (2004) 53: 3267-73 [PMID:15561959] |
| GtoPdb | - | - | 7.5 | pIC50 | - | - | - | Bioorg Med Chem Lett (2005) 15: 1401-5 [PMID:15713396] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
