ChEMBL ligand: CHEMBL2103863 (Abexinostat, CRA 024781, CRA-024781, CRA 24781, PCI 24781, PCI-24781, PZP115891, PZP-115891, S78454, S-78454)
histone deacetylase 1/Histone deacetylase 1 in Human [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 10/Histone deacetylase 10 in Human [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 11/Histone deacetylase 11 in Human [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 2/Histone deacetylase 2 in Human [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3 in Human [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 4/Histone deacetylase 4 in Human [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 5/Histone deacetylase 5 in Human [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 7/Histone deacetylase 7 in Human [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 8/Histone deacetylase 8 in Human [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 9/Histone deacetylase 9 in Human [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0] There should be some charts here, you may need to enable JavaScript!
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
histone deacetylase 1/Histone deacetylase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL325] [GtoPdb: 2658] [UniProtKB: Q13547]
ChEMBL	Inhibition of HDAC1 (unknown origin)	B	8	pKi	10	nM	Ki	Eur J Med Chem (2017) 135: 174-195 [PMID:28453994]
ChEMBL	Inhibition of human HDAC1	B	8.15	pKi	7	nM	Ki	Bioorg. Med. Chem. (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human HDAC1 expressed in baculovirus infected sf9 cells using p53 residues 379-382 (RHKKAc) as substrate by fluorescence-based assay	B	7.68	pIC50	21	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
GtoPdb	-	-	8.15	pIC50	7	nM	IC50	Mol Cancer Ther (2006) 5: 1309-17 [PMID:16731764]
histone deacetylase 10/Histone deacetylase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5103] [GtoPdb: 2614] [UniProtKB: Q969S8]
ChEMBL	Inhibition of human HDAC10	B	7.62	pKi	24	nM	Ki	Bioorg. Med. Chem. (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of HDAC10 (unknown origin)	B	7.7	pKi	20	nM	Ki	Eur J Med Chem (2017) 135: 174-195 [PMID:28453994]
ChEMBL	Inhibition of HDAC10 (unknown origin)	B	7.28	pIC50	52	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
ChEMBL	Inhibition of dye-labeled tracer binding to HDAC10 (unknown origin) transfected in human HeLa cells measured after 2 hrs by nano-luciferase reporter gene-based BRET assay	B	8.1	pIC50	7.94	nM	IC50	J Med Chem (2019) 62: 4426-4443 [PMID:30964290]
ChEMBL	Inhibition of tubastatin-Alexa647-tracer binding to recombinant GST-tagged HDAC10 (unknown origin) measured after 1 hr by TR-FRET assay	B	8.4	pIC50	3.98	nM	IC50	J Med Chem (2019) 62: 4426-4443 [PMID:30964290]
histone deacetylase 11/Histone deacetylase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3310] [GtoPdb: 2615] [UniProtKB: Q96DB2]
ChEMBL	Inhibition of human HDAC11 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	7.85	pIC50	14	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 2/Histone deacetylase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1937] [GtoPdb: 2616] [UniProtKB: Q92769]
ChEMBL	Inhibition of HDAC2 (unknown origin)	B	7.7	pKi	20	nM	Ki	Eur J Med Chem (2017) 135: 174-195 [PMID:28453994]
ChEMBL	Inhibition of human HDAC2	B	7.72	pKi	19	nM	Ki	Bioorg. Med. Chem. (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human HDAC2 expressed in baculovirus infected sf9 cells using p53 residues 379-382 (RHKKAc) as substrate by fluorescence-based assay	B	7.2	pIC50	63	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 3/Histone deacetylase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1829] [GtoPdb: 2617] [UniProtKB: O15379]
ChEMBL	Inhibition of HDAC3 (unknown origin)	B	8	pKi	10	nM	Ki	Eur J Med Chem (2017) 135: 174-195 [PMID:28453994]
ChEMBL	Inhibition of human HDAC3	B	8.09	pKi	8.2	nM	Ki	Bioorg. Med. Chem. (2015) 23: 5151-5155 [PMID:25637120]
GtoPdb	-	-	8.09	pIC50	8.2	nM	IC50	Mol Cancer Ther (2006) 5: 1309-17 [PMID:16731764]
histone deacetylase 3/Histone deacetylase 3/Nuclear receptor corepressor 2 (HDAC3/NCoR2) in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111363] [GtoPdb: 2617] [UniProtKB: O15379, Q9Y618]
ChEMBL	Inhibition of human HDAC3/NcoR2 expressed in sf9 cells using p53 residues 379-382 (RHKKAc) as substrate by fluorescence-based assay	B	6.83	pIC50	148	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
GtoPdb	-	-	8.09	pIC50	8.2	nM	IC50	Mol Cancer Ther (2006) 5: 1309-17 [PMID:16731764]
histone deacetylase 4/Histone deacetylase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3524] [GtoPdb: 2659] [UniProtKB: P56524]
ChEMBL	Inhibition of human HDAC4 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	7.22	pIC50	60	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 5/Histone deacetylase 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2563] [GtoPdb: 2660] [UniProtKB: Q9UQL6]
ChEMBL	Inhibition of human HDAC5 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	7.32	pIC50	48	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Inhibition of HDAC6 (unknown origin)	B	7.7	pKi	20	nM	Ki	Eur J Med Chem (2017) 135: 174-195 [PMID:28453994]
ChEMBL	Inhibition of human HDAC6	B	7.77	pKi	17	nM	Ki	Bioorg. Med. Chem. (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of human HDAC6 expressed in baculovirus infected sf9 cells using p53 residues 379-382 (RHKKAc) as substrate by fluorescence-based assay	B	7.92	pIC50	12	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 7/Histone deacetylase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2716] [GtoPdb: 2661] [UniProtKB: Q8WUI4]
ChEMBL	Inhibition of human HDAC7 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	6.46	pIC50	350	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 8/Histone deacetylase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3192] [GtoPdb: 2619] [UniProtKB: Q9BY41]
ChEMBL	Inhibition of human HDAC8	B	6.55	pKi	280	nM	Ki	Bioorg. Med. Chem. (2015) 23: 5151-5155 [PMID:25637120]
ChEMBL	Inhibition of HDAC8 (unknown origin)	B	6.55	pKi	280	nM	Ki	Eur J Med Chem (2017) 135: 174-195 [PMID:28453994]
ChEMBL	Inhibition of human HDAC8 expressed in baculovirus infected sf9 cells using p53 residues 379-382 (RHKAcKAc) as substrate by fluorescence-based assay	B	6.43	pIC50	370	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
histone deacetylase 9/Histone deacetylase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4145] [GtoPdb: 2620] [UniProtKB: Q9UKV0]
ChEMBL	Inhibition of human HDAC9 expressed in baculovirus infected sf9 cells using (Boc-Lys(trifluoroacetyl)-AMC) as substrate by fluorescence-based assay	B	6.77	pIC50	168	nM	IC50	J Med Chem (2020) 63: 12460-12484 [PMID:32608981]
Leukotriene A4 hydrolase/Leukotriene A4 hydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4618] [GtoPdb: 1395] [UniProtKB: P09960]
ChEMBL	Inhibition of recombinant human LTA4H Epoxide Hydrolase expressed in Escherichia coli BL21 (DE3) pLysS preincubated for 10 mins followed by addition of LTA4 as substrate measured after 15 mins by reverse-phase HPLC analysis	B	5	pIC50	>10000	nM	IC50	J Med Chem (2017) 60: 1817-1828 [PMID:28218840]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]