pholcodine   Click here for help

GtoPdb Ligand ID: 9086

Synonyms: Covonia Dry Cough® | Galenphol® | Pavacol-D®
Approved drug
pholcodine is an approved drug (UK (1993))
Compound class: Synthetic organic
Comment: Pholcodine is an opioid cough suppressant (antitussive). It helps suppress unproductive coughs, has a mild sedative effect, but very limited analgesic effects.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 54.4
Molecular weight 398.22
XLogP 0.26
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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Canonical SMILES CN1CCC23C4C1Cc1c3c(OC2C(C=C4)O)c(cc1)OCCN1CCOCC1
Isomeric SMILES CN1CC[C@@]23[C@@H]4[C@H]1Cc1c3c(O[C@H]2[C@H](C=C4)O)c(cc1)OCCN1CCOCC1
InChI InChI=1S/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16-,17+,18-,22-,23-/m0/s1
InChI Key GPFAJKDEDBRFOS-FKQDBXSBSA-N
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (UK (1993))
IUPAC Name Click here for help
(4R,4aR,7S,7aR,12bS)-3-methyl-9-(2-morpholin-4-ylethoxy)-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7-o
International Nonproprietary Names Click here for help
INN number INN
272 pholcodine
Synonyms Click here for help
Covonia Dry Cough® | Galenphol® | Pavacol-D®
Database Links Click here for help
CAS Registry No. 509-67-1 (source: PubChem)
ChEMBL Ligand CHEMBL2105224
DrugBank Ligand DB09209
DrugCentral Ligand 2154
GtoPdb PubChem SID 315661171
PubChem CID 5311356
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Wikipedia Pholcodine