pholcodine   Click here for help

GtoPdb Ligand ID: 9086

Synonyms: Covonia Dry Cough® | Galenphol® | Pavacol-D®
Approved drug
pholcodine is an approved drug (UK (1993))
Compound class: Synthetic organic
Comment: Pholcodine is an opioid cough suppressant (antitussive). It helps suppress unproductive coughs, has a mild sedative effect, but very limited analgesic effects.
IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: pholcodine

2D Structure
Click here for help
Click here for structure editor
Physico-chemical Properties
Click here for help
Hydrogen bond acceptors 4
Hydrogen bond donors 1
Rotatable bonds 4
Topological polar surface area 54.4
Molecular weight 398.22
XLogP 0.26
No. Lipinski's rules broken 0
Click here for help
Canonical SMILES CN1CCC23C4C1Cc1c3c(OC2C(C=C4)O)c(cc1)OCCN1CCOCC1
Isomeric SMILES CN1CC[C@@]23[C@@H]4[C@H]1Cc1c3c(O[C@H]2[C@H](C=C4)O)c(cc1)OCCN1CCOCC1
InChI InChI=1S/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16-,17+,18-,22-,23-/m0/s1
Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (UK (1993))
IUPAC Name Click here for help
International Nonproprietary Names Click here for help
INN number INN
272 pholcodine
Synonyms Click here for help
Covonia Dry Cough® | Galenphol® | Pavacol-D®
Database Links Click here for help
CAS Registry No. 509-67-1 (source: PubChem)
ChEMBL Ligand CHEMBL2105224
DrugBank Ligand DB09209
DrugCentral Ligand 2154
GtoPdb PubChem SID 315661171
PubChem CID 5311356
Search Google for chemical match using the InChIKey GPFAJKDEDBRFOS-FKQDBXSBSA-N
Search Google for chemicals with the same backbone GPFAJKDEDBRFOS
Search PubMed clinical trials pholcodine
Search PubMed titles pholcodine
Search PubMed titles/abstracts pholcodine
UniChem Compound Search for chemical match using the InChIKey GPFAJKDEDBRFOS-FKQDBXSBSA-N
UniChem Connectivity Search for chemical match using the InChIKey GPFAJKDEDBRFOS-FKQDBXSBSA-N
Wikipedia Pholcodine