pholcodine

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Ligands
pholcodine

GtoPdb Ligand ID: 9086

Synonyms: Covonia Dry Cough® | Galenphol® | Pavacol-D®

pholcodine is an approved drug (UK (1993))

Comment: Pholcodine is an opioid cough suppressant (antitussive). It helps suppress unproductive coughs, has a mild sedative effect, but very limited analgesic effects.

View more information in the IUPHAR Pharmacology Education Project: pholcodine

2D Structure

Physico-chemical Properties

Hydrogen bond acceptors	4
Hydrogen bond donors	1
Rotatable bonds	4
Topological polar surface area	54.4
Molecular weight	398.22
XLogP	0.26
No. Lipinski's rules broken	0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

SMILES / InChI / InChIKey

Canonical SMILES	CN1CCC23C4C1Cc1c3c(OC2C(C=C4)O)c(cc1)OCCN1CCOCC1
Isomeric SMILES	CN1CC[C@@]23[C@@H]4[C@H]1Cc1c3c(O[C@H]2[C@H](C=C4)O)c(cc1)OCCN1CCOCC1
InChI	InChI=1S/C23H30N2O4/c1-24-7-6-23-16-3-4-18(26)22(23)29-21-19(5-2-15(20(21)23)14-17(16)24)28-13-10-25-8-11-27-12-9-25/h2-5,16-18,22,26H,6-14H2,1H3/t16-,17+,18-,22-,23-/m0/s1
InChI Key	GPFAJKDEDBRFOS-FKQDBXSBSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)