Akt inhibitor VIII [Ligand Id: 5921] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL258844 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| AKT serine/threonine kinase 1/Serine/threonine-protein kinase AKT in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4282] [GtoPdb: 1479] [UniProtKB: P31749] | ||||||||
| ChEMBL | Inhibition of Akt1 by cell-based IPKA assay | B | 6.52 | pIC50 | 305 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of Akt1 by cell-based assay | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3178-3182 [PMID:18479914] |
| ChEMBL | Inhibition of Akt1 | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of human recombinant Akt1 | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2211-2214 [PMID:18296048] |
| ChEMBL | Inhibition of Akt1 | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3178-3182 [PMID:18479914] |
| ChEMBL | Inhibition of Akt1 | B | 7.24 | pIC50 | 58 | nM | IC50 | J Med Chem (2010) 53: 1413-1437 [PMID:20166671] |
| ChEMBL | Inhibitory concentration against Akt1 kinase | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 905-909 [PMID:15686884] |
| ChEMBL | Inhibition of Akt1 (unknown origin) | B | 7.24 | pIC50 | 58 | nM | IC50 | Eur J Med Chem (2016) 113: 214-227 [PMID:26945110] |
| ChEMBL | Inhibitory concentration against human Protein kinase B, alpha | B | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-764 [PMID:15664853] |
| GtoPdb | - | - | 7.24 | pIC50 | 58 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-4 [PMID:15664853] |
| AKT serine/threonine kinase 2/Serine/threonine-protein kinase AKT2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2431] [GtoPdb: 1480] [UniProtKB: P31751] | ||||||||
| ChEMBL | Inhibitory concentration against Akt3 kinase | B | 5.66 | pIC50 | >2200 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 905-909 [PMID:15686884] |
| ChEMBL | Inhibition of Akt2 by cell-based IPKA assay | B | 5.68 | pIC50 | 2100 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of Akt2 by cell-based assay | B | 6.05 | pIC50 | 900 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3178-3182 [PMID:18479914] |
| ChEMBL | Inhibition of Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 3178-3182 [PMID:18479914] |
| ChEMBL | Inhibition of Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | J Med Chem (2010) 53: 1413-1437 [PMID:20166671] |
| ChEMBL | Inhibition of human recombinant Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2211-2214 [PMID:18296048] |
| ChEMBL | Inhibitory concentration against human Protein kinase B, Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-764 [PMID:15664853] |
| ChEMBL | Inhibition of Akt2 | B | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| GtoPdb | - | - | 6.68 | pIC50 | 210 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-4 [PMID:15664853] |
| ChEMBL | Inhibition of Akt2 (unknown origin) | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2016) 113: 214-227 [PMID:26945110] |
| AKT serine/threonine kinase 3/Serine/threonine-protein kinase AKT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4816] [GtoPdb: 2286] [UniProtKB: Q9Y243] | ||||||||
| ChEMBL | Inhibition of Akt3 by cell-based IPKA assay | B | 5 | pIC50 | >=10000 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of Akt3 | B | 5.66 | pIC50 | 2200 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 49-53 [PMID:18054229] |
| ChEMBL | Inhibition of Akt3 (unknown origin) | B | 5.66 | pIC50 | 2200 | nM | IC50 | Eur J Med Chem (2016) 113: 214-227 [PMID:26945110] |
| GtoPdb | - | - | 5.67 | pIC50 | 2119 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-4 [PMID:15664853] |
| ChEMBL | Inhibitory concentration against human Protein kinase B, Akt3 | B | 5.67 | pIC50 | 2119 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 761-764 [PMID:15664853] |
| ChEMBL | Inhibition of human recombinant Akt3 | B | 5.67 | pIC50 | >2119 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 2211-2214 [PMID:18296048] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
