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ChEMBL ligand: CHEMBL2069623 (PF-4800567) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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casein kinase 1 delta/Casein kinase I delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2828] [GtoPdb: 1997] [UniProtKB: P48730] | ||||||||
ChEMBL | Inhibition of CK1delta | B | 6.15 | pIC50 | 711 | nM | IC50 | Eur J Med Chem (2012) 56: 30-38 [PMID:22944772] |
ChEMBL | Inhibition of Casein kinase 1 delta | B | 6.15 | pIC50 | 711 | nM | IC50 | J Med Chem (2012) 55: 10307-10311 [PMID:23106386] |
ChEMBL | Inhibition of human CK1delta in presence of [gamma33P]-ATP | B | 6.15 | pIC50 | 711 | nM | IC50 | Eur J Med Chem (2019) 181: 111581-111581 [PMID:31400711] |
GtoPdb | - | - | 6.15 | pIC50 | 711 | nM | IC50 | J Pharmacol Exp Ther (2009) 330: 430-9 [PMID:19458106] |
ChEMBL | Inhibition of human full length CK1delta1 (2 to 415 residues) using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assay | B | 7.49 | pIC50 | 32 | nM | IC50 | Nat Rev Drug Discov (2017) 16: 424-440 [PMID:28280261] |
casein kinase 1 epsilon/Casein kinase I epsilon in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4937] [GtoPdb: 1998] [UniProtKB: P49674] | ||||||||
GtoPdb | - | - | 7.49 | pIC50 | 32 | nM | IC50 | J Pharmacol Exp Ther (2009) 330: 430-9 [PMID:19458106] |
ChEMBL | Inhibition of CK1epsilon | B | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2012) 56: 30-38 [PMID:22944772] |
ChEMBL | Inhibition of Casein kinase 1 epsilon | B | 7.49 | pIC50 | 32 | nM | IC50 | J Med Chem (2012) 55: 10307-10311 [PMID:23106386] |
ChEMBL | Inhibition of human full length polyhistidine-tagged CK1epsilon expressed in Escherichia coli BL21-Codon-Plus (DE3)-RIL using PLSRTLpSVASLPGL as substrate after 2 hrs by kinase-glo assay | B | 7.49 | pIC50 | 32 | nM | IC50 | Nat Rev Drug Discov (2017) 16: 424-440 [PMID:28280261] |
ChEMBL | Inhibition of human CK1epsilon in presence of [gamma33P]-ATP | B | 7.49 | pIC50 | 32 | nM | IC50 | Eur J Med Chem (2019) 181: 111581-111581 [PMID:31400711] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]