Ro64-6198 [Ligand Id: 1684] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2088034 (Ro-646198) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
| NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] | ||||||||
| ChEMBL | Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter | B | 8.95 | pKi | 1.12 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
| GtoPdb | - | - | 9.41 | pKi | - | - | - |
Proc Natl Acad Sci USA (2000) 97: 4938-43 [PMID:10758169]; Eur J Med Chem (2000) 35: 839-51 [PMID:11006485] |
| GtoPdb | Stimulation of GTPγ35S binding | - | 7.41 | pEC50 | - | - | - | Eur J Med Chem (2000) 35: 839-51 [PMID:11006485] |
| ChEMBL | Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay | F | 7.68 | pEC50 | 21 | nM | EC50 | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
