Ro64-6198 [Ligand Id: 1684] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2088034 (Ro-646198) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
| κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
| μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| ChEMBL | Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter | B | 6.4 | pKi | >400 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
| NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] | ||||||||
| ChEMBL | Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter | B | 8.95 | pKi | 1.12 | nM | Ki | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
| GtoPdb | - | - | 9.41 | pKi | - | - | - |
Proc Natl Acad Sci USA (2000) 97: 4938-43 [PMID:10758169]; Eur J Med Chem (2000) 35: 839-51 [PMID:11006485] |
| GtoPdb | Stimulation of GTPγ35S binding | - | 7.41 | pEC50 | - | - | - | Eur J Med Chem (2000) 35: 839-51 [PMID:11006485] |
| ChEMBL | Agonist activity at human cloned NOP receptor expressed in CHO cell membranes after 30 mins by [35S]GTPgammaS binding assay | F | 7.68 | pEC50 | 21 | nM | EC50 | J Med Chem (2012) 55: 4955-4967 [PMID:22541041] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
