ACHN-975 [Ligand Id: 13333] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3939284 (Achn-975, ACHN-975) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| UDP-3-O-acyl-GlcNAc deacetylase in Pseudomonas aeruginosa (strain ATCC 15692 / PAO1 / 1C / PRS 101 / LMG12228) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3855] [UniProtKB: P47205] | ||||||||
| ChEMBL | Inhibition of wild-type Pseudomonas aeruginosa LpxC preincubated for 20 mins followed by addition of UDP-3-O-(R-hydroxydecanoyl)-N-acetylglucosamine as substrate measured after 60 mins by HPLC analysis | B | 10.7 | pIC50 | 0.02 | nM | IC50 | Bioorg Med Chem (2016) 24: 6320-6331 [PMID:27178386] |
| UDP-3-O-acyl-N-acetylglucosamine deacetylase in Pseudomonas aeruginosa (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2163170] [UniProtKB: B5ATN6] | ||||||||
| ChEMBL | Inhibition of recombinant Pseudomonas aeruginosa LpxC expressed in Escherichia coli | B | 9.17 | pIC50 | 0.68 | nM | IC50 | Eur J Med Chem (2023) 253: 115326-115326 [PMID:37023679] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
