ChEMBL ligand: CHEMBL77502
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL	Agonist activity at PPARalpha	F	7.35	pIC50	44.98	nM	IC50	Bioorg. Med. Chem. (2012) 20: 3523-3532 [PMID:22564380]
GtoPdb	-	-	7.55	pIC50	-	-	-	J Med Chem (2004) 47: 2422-5 [PMID:15115385]
ChEMBL	Displacement of PPAR-alpha/delta agonist from human Peroxisome proliferator activated receptor alpha	F	7.55	pIC50	28	nM	IC50	J. Med. Chem. (2004) 47: 2422-2425 [PMID:15115385]
ChEMBL	Agonist activity at PPARalpha	F	7.55	pIC50	28	nM	IC50	Bioorg. Med. Chem. (2012) 20: 3523-3532 [PMID:22564380]
ChEMBL	Transcriptional activation of reporter assay by human Peroxisome proliferator activated receptor alpha in CV-1 cells	B	8.05	pEC50	9	nM	EC50	J. Med. Chem. (2004) 47: 2422-2425 [PMID:15115385]
ChEMBL	Transactivation of GAL4-fused Homo sapiens (human) PPARalpha DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter gene assay	B	8.05	pEC50	9	nM	EC50	Med Chem Res (2013) 22: 287-302
ChEMBL	Transactivation of Homo sapiens (human) PPARalpha assessed as luciferase activity by reporter gene assay	B	8.05	pEC50	8.91	nM	EC50	Med Chem Res (2012) 21: 2873-2884
ChEMBL	Transactivation of GAL4-fused Homo sapiens (human) PPARalpha DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter gene assay	B	8.05	pEC50	8.91	nM	EC50	Med Chem Res (2013) 22: 287-302
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
ChEMBL	Displacement of PPAR-alpha/delta agonist from human Peroxisome proliferator activated receptor delta	F	5.28	pIC50	5253	nM	IC50	J. Med. Chem. (2004) 47: 2422-2425 [PMID:15115385]
ChEMBL	Agonist activity at PPARdelta	F	5.28	pIC50	5253	nM	IC50	Bioorg. Med. Chem. (2012) 20: 3523-3532 [PMID:22564380]
ChEMBL	Agonist activity at PPARdelta	F	5.28	pIC50	5248.07	nM	IC50	Bioorg. Med. Chem. (2012) 20: 3523-3532 [PMID:22564380]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Agonist activity at PPARgamma	F	7.62	pIC50	23.99	nM	IC50	Bioorg. Med. Chem. (2012) 20: 3523-3532 [PMID:22564380]
GtoPdb	-	-	8	pIC50	-	-	-	Ann NY Acad Sci (1988) 547: 1-541 [PMID:3071214]; J Med Chem (2004) 47: 2422-5 [PMID:15115385]
ChEMBL	Displacement of PPARgamma agonist from human PPAR gamma receptor	F	8	pIC50	10	nM	IC50	J. Med. Chem. (2004) 47: 2422-2425 [PMID:15115385]
ChEMBL	Agonist activity at PPARgamma	F	8	pIC50	10	nM	IC50	Bioorg. Med. Chem. (2012) 20: 3523-3532 [PMID:22564380]
ChEMBL	Transcriptional activation of reporter assay by PPAR gamma receptor in CV-1 cells	B	8.4	pEC50	4	nM	EC50	J. Med. Chem. (2004) 47: 2422-2425 [PMID:15115385]
ChEMBL	Transactivation of GAL4-fused Homo sapiens (human) PPARgamma DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter gene assay	B	8.4	pEC50	4	nM	EC50	Med Chem Res (2013) 22: 287-302
ChEMBL	Transactivation of Homo sapiens (human) PPARgamma assessed as luciferase activity by reporter gene assay	B	8.4	pEC50	3.98	nM	EC50	Med Chem Res (2012) 21: 2873-2884
ChEMBL	Transactivation of GAL4-fused Homo sapiens (human) PPARgamma DNA binding domain expressed in African green monkey CV1 cells by luciferase reporter gene assay	B	8.4	pEC50	3.98	nM	EC50	Med Chem Res (2013) 22: 287-302

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]