ChEMBL ligand: CHEMBL498270
KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554] There should be some charts here, you may need to enable JavaScript!
Kv1.3/Voltage-gated potassium channel subunit Kv1.3 in Human [ChEMBL: CHEMBL4633] [GtoPdb: 540] [UniProtKB: P22001] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554]
GtoPdb	-	-	8	pKd	-	-	-	Proc Natl Acad Sci USA (2000) 97: 8151-6 [PMID:10884437]; Circulation (2003) 108: 1119-25 [PMID:12939222]
ChEMBL	Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay	B	7.7	pIC50	20	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171]
ChEMBL	Inhibition of IK1	B	7.7	pIC50	20	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171]
Kv1.3/Voltage-gated potassium channel subunit Kv1.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4633] [GtoPdb: 540] [UniProtKB: P22001]
ChEMBL	Inhibition of cloned Kv1.3 channel expressed in mammalian cells by whole cell patch clamp assay	B	5.3	pIC50	5000	nM	IC50	Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]