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ChEMBL ligand: CHEMBL498270 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
GtoPdb | - | - | 8 | pKd | - | - | - |
Proc Natl Acad Sci USA (2000) 97: 8151-6 [PMID:10884437]; Circulation (2003) 108: 1119-25 [PMID:12939222] |
ChEMBL | Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171] |
ChEMBL | Inhibition of IK1 | B | 7.7 | pIC50 | 20 | nM | IC50 | Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171] |
Kv1.3/Voltage-gated potassium channel subunit Kv1.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4633] [GtoPdb: 540] [UniProtKB: P22001] | ||||||||
ChEMBL | Inhibition of cloned Kv1.3 channel expressed in mammalian cells by whole cell patch clamp assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]