TRAM-34 [Ligand Id: 2336] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL498270
  • KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554]
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  • Kv1.3/Voltage-gated potassium channel subunit Kv1.3 in Human [ChEMBL: CHEMBL4633] [GtoPdb: 540] [UniProtKB: P22001]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
KCa3.1/Intermediate conductance calcium-activated potassium channel protein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4305] [GtoPdb: 384] [UniProtKB: O15554]
GtoPdb - - 8 pKd - - - Proc Natl Acad Sci USA (2000) 97: 8151-6 [PMID:10884437];
Circulation (2003) 108: 1119-25 [PMID:12939222]
ChEMBL Inhibition of human cloned IK1 expressed in african green monkey COS7 cells by whole cell patch clamp assay B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171]
ChEMBL Inhibition of IK1 B 7.7 pIC50 20 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171]
Kv1.3/Voltage-gated potassium channel subunit Kv1.3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4633] [GtoPdb: 540] [UniProtKB: P22001]
ChEMBL Inhibition of cloned Kv1.3 channel expressed in mammalian cells by whole cell patch clamp assay B 5.3 pIC50 5000 nM IC50 Bioorg. Med. Chem. Lett. (2009) 19: 2299-2304 [PMID:19282171]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]